Formaldehyde → HCID 54232589、化合物

HRID 1446834ノート

反応式

HRID 1446834 の反応式
N[C:2]1[C:7]([C:8](=[O:15])[C:9]2[CH:14]=[CH:13][CH:12]=[CH:11][CH:10]=2)=[CH:6][CH:5]=[CH:4][C:3]=1[CH2:16][C:17]([NH2:19])=[O:18].[CH2:20]=O.[C:22]([BH3-])#[N:23].[Na+].[OH-].[Na+]>C(#N)C.C(O)(=O)C>[C:8]([C:7]1[C:2]([N:23]([CH3:22])[CH3:20])=[C:3]([CH2:16][C:17]([NH2:19])=[O:18])[CH:4]=[CH:5][CH:6]=1)(=[O:15])[C:9]1[CH:14]=[CH:13][CH:12]=[CH:11][CH:10]=1

参加物

7

反応物 4

HCID 712FormaldehydeHCID 14798Sodium HydroxideHCID 151075NepafenacHCID 5003444Sodium cyanoborohydride

生成物 1

HCID 54232589HCID 54232589、化合物

試薬・触媒・溶媒 2

HCID 176Acetic Acid溶媒HCID 6342Acetonitrile溶媒

実験手順

A solution of 12.7 g (0.05 mol) of 2-amino-3-benzoyl-phenylacetamide in 150 ml of acetonitrile is treated four times with 16 ml (0.2 mole) of 37% formalin, 6.4 g (0.1 mole) of sodium cyanoborohydride and 2 ml of glacial acetic acid with a 15 minute stirring period between each treatment. The mixture is finally poured into dilute sodium hydroxide and extracted three times with diethylether. The ether extracts are combined, dried over magnesium sulfate and concentrated. The product is isolated by column chromatography.

後処理

  1. extractionextracted three times with diethylether
  2. dry with materialdried over magnesium sulfate
  3. concentrationconcentrated
  4. customThe product is isolated by column chromatography

出典と根拠

ORDレコード
ord-c16df1c2c8d04b8da75839f95b0e666d
出典データセット
uspto-grants-1982_02
特許番号
US04313949

反応ノート

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