反応式
[C:1](Cl)(=O)[C:2]([Cl:4])=[O:3].[CH3:7][N:8]([CH2:10][C:11]1[CH:19]=[CH:18]C(C(O)=O)=[CH:13][CH:12]=1)[CH3:9].NCC1C=CC(C(OC)=O)=CC=1.C=O.[OH-].[Na+]>>[CH3:7][N:8]([CH2:10][C:11]1[CH:19]=[CH:18][C:1]([C:2]([Cl:4])=[O:3])=[CH:13][CH:12]=1)[CH3:9]参加物
6
実験手順
The 4-(N,N-dimethylaminomethyl) benzoyl chloride was prepared by reacting the acid with excess oxalyl chloride for 1 hr at 25° C. The 4-(N,N-dimethylaminomethyl) benzoic acid was in turn prepared from methyl 4-aminomethylbenzoate via reductive alkylation (CH2O, Na(OAc)3 BH as in J. Org. Chem., 1972, 37, 1673) followed by hydrolysis using 10% aqueous NaOH.
後処理
- customfor 1 hr
- customat 25° C
- customfollowed by hydrolysis
出典と根拠
- ORDレコード
- ord-d77ffea2c0ff485a9d1599781addece9
- 出典データセット
- uspto-grants-1998_12
- 特許番号
- US05843905
関連ノート
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