1-(2-Methoxyphenyl)isoquinoline → 1-[2-Methoxy-6-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)phenyl]isoquinoline

HRID 1491494

反応式

HRID 1491494 の反応式
COc1ccccc1-c1nccc2ccccc12>C(=NN(Cc1ccccc1)Cc1ccccc1)c1ccccn1.C1=CCCC=CCC1.C1=CCCC=CCC1.C1CCOC1.CC1(C)OB(B2OC(C)(C)C(C)(C)O2)OC1(C)C.CC1(C)OBOC1(C)C.C[OH2+].C[OH2+].[Ir].[Ir]>COc1cccc(B2OC(C)(C)C(C)(C)O2)c1-c1nccc2ccccc12

参加物

7

反応物 1

HCID 231597341-(2-Methoxyphenyl)isoquinoline

生成物 1

HCID 1015479381-[2-Methoxy-6-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)phenyl]isoquinoline収率 88%

試薬・触媒・溶媒 5

HCID 2733548Bis(pinacolato)diborane試薬HCID 27347684,4,5,5-Tetramethyl[1,3,2]dioxaborolane試薬HCID 67601456N,N-Dibenzyl-N'-(pyridin-2-ylmethylene)hydrazine試薬HCID 76001521Bis(1,5-cyclooctadiene)dimethoxydiiridium触媒HCID 8028Tetrahydrofuran溶媒

反応条件

温度
50 °C

実験手順

Following the general procedure, precipitation from the reaction crude with hexane and trituration afforded 9i (159 mg, 88 %) as a pale solid.

出典と根拠

ORDレコード
ord-2dd73b1c305947e1a593c90545f7d2d2
出典データセット
Borylation dataset from Roche

関連ノート

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