Pyridine → Phenyl (6-methoxypyrazin-2-yl)carbamate
反応式
[NH2:1][C:2]1[CH:7]=[N:6][CH:5]=[C:4]([O:8][CH3:9])[N:3]=1.CC#N.N1C=CC=CC=1.[C:19]1([O:25][C:26](Cl)=[O:27])[CH:24]=[CH:23][CH:22]=[CH:21][CH:20]=1>C1COCC1>[CH3:9][O:8][C:4]1[N:3]=[C:2]([NH:1][C:26](=[O:27])[O:25][C:19]2[CH:24]=[CH:23][CH:22]=[CH:21][CH:20]=2)[CH:7]=[N:6][CH:5]=1参加物
6
実験手順
2-Amino-6-methoxy-pyrazine (1.00 g, 8 mmol) was dissolved in a mix of 1:2 THF:MeCN (30 mL), cooled to 0° C., and treated with pyridine (0.664 g, 8.3 mmol) followed by the dropwise addition of phenylchloroformate (1.3 g, 8.3 mmol) in THF (10 mL). After stirring for 18 h, the resulting white solid was collected by filtration (1.3 g, 68%) and was used without further purification.
後処理
- filtrationthe resulting white solid was collected by filtration (1.3 g, 68%)
- customwas used without further purification
出典と根拠
- ORDレコード
- ord-b1d53a37aed0422eaba5b63a3da91fa7
- 出典データセット
- uspto-grants-2011_10
- 特許番号
- US08044052B2
反応ノート
読み込み中…