Pyridine → Phenyl 3-methylpyrazin-2-ylcarbamate

HRID 1666359

反応式

HRID 1666359 の反応式
[NH2:1][C:2]1[C:7]([CH3:8])=[N:6][CH:5]=[CH:4][N:3]=1.CC#N.N1C=CC=CC=1.[C:18]1([O:24][C:25](Cl)=[O:26])[CH:23]=[CH:22][CH:21]=[CH:20][CH:19]=1>C1COCC1>[CH3:8][C:7]1[C:2]([NH:1][C:25](=[O:26])[O:24][C:18]2[CH:23]=[CH:22][CH:21]=[CH:20][CH:19]=2)=[N:3][CH:4]=[CH:5][N:6]=1

参加物

6

反応物 4

HCID 1049PyridineHCID 6342AcetonitrileHCID 15891Phenyl chloroformateHCID 3022842-Amino-3-methylpyrazine

生成物 1

HCID 66875712Phenyl 3-methylpyrazin-2-ylcarbamate

試薬・触媒・溶媒 1

HCID 8028Tetrahydrofuran溶媒2 回

実験手順

A solution of 2-amino-3-methyl-pyrazine (1.50 g, 1.37 mmol) in a mix of 1:2 THF:MeCN (30 mL), and pyridine (0.664 g, 1.44 mmol) was treated dropwise with phenylchloroformate (1.3 g, 1.44 mmol) in THF (10 mL). After stirring for 18 h, the reaction mixture was concentrated in vacuo to a solid and was used without further purification.

後処理

  1. concentrationthe reaction mixture was concentrated in vacuo to a solid
  2. customwas used without further purification

出典と根拠

ORDレコード
ord-d151172da7374fd68c235531ce430bd0
出典データセット
uspto-grants-2011_10
特許番号
US08044052B2

関連ノート

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