Methyl Methacrylate → Cholesterol

HRID 1823698ノート

反応式

HRID 1823698 の反応式
CCCCCCCCC([O:11][C@@H:12]1[CH2:25][C:24]2[C@@:15]([CH3:38])([C@@H:16]3[C@@H:21]([CH2:22][CH:23]=2)[C@@H:20]2[CH2:26][CH2:27][C@H:28]([C@@H:29]([CH2:31][CH2:32][CH2:33][CH:34]([CH3:36])[CH3:35])[CH3:30])[C@@:19]2([CH3:37])[CH2:18][CH2:17]3)[CH2:14][CH2:13]1)=O.COC(=O)C(C)=C.N(C(C)(CC)C#N)=NC(C)(CC)C#N.[N+]([O-])([O-])=O.[Na+]>C(Cl)Cl>[CH3:36][CH:34]([CH2:33][CH2:32][CH2:31][C@H:29]([C@@H:28]1[C@:19]2([CH3:37])[C@H:20]([C@H:21]3[C@H:16]([CH2:17][CH2:18]2)[C@:15]2([CH3:38])[C:24]([CH2:25][C@H:12]([CH2:13][CH2:14]2)[OH:11])=[CH:23][CH2:22]3)[CH2:26][CH2:27]1)[CH3:30])[CH3:35]

参加物

6

反応物 4

HCID 6658Methyl MethacrylateHCID 24268Sodium NitrateHCID 930792,2'-Azobis(2-methylbutyronitrile)HCID 2723614Cholesteryl Nonanoate

生成物 1

HCID 5997Cholesterol

試薬・触媒・溶媒 1

HCID 6344Dichloromethane溶媒

反応条件

温度
60 °C

実験手順

30 wt % of cholesteryl nonanoate and 70 wt % of methylmethacrylate monomer were dissolved uniformly in 20 ml of methylene chloride under irradiation of ultrasonic wave. As an initiator, 2,2′-azobis(2-methylbutyronitrile) was added thereto in an amount of 1 wt % based on the weight of monomer. The obtained solution was added into 1.5% aqueous solution of polyvinyl alcohol with 87˜89% of saponification value and then was emulsified under 5,000 rpm of shear stress for 5 minutes. The emulsion and 0.01 wt % of sodium nitrate were introduced into the reactor heated at 60° C. and then polymerized for 4 hours. After the polymerization was terminated, the organic solvent was evaporated off under reduced pressure. The residue was filtrated, washed with distilled water several times, and then dried on vacuum oven, to give cholesterol liquid crystal polymer microcapsules as powders.

後処理

  1. custompolymerized for 4 hours
  2. customAfter the polymerization was terminated
  3. customthe organic solvent was evaporated off under reduced pressure
  4. filtrationThe residue was filtrated
  5. washwashed with distilled water several times
  6. customdried on vacuum oven

出典と根拠

ORDレコード
ord-b7ff2b3d31c34acfbba430d7754815b2
出典データセット
uspto-grants-2006_05
特許番号
US07041304B2

反応ノート

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