Diisopropylethylamine → HCID 178517175、化合物

HRID 221985

反応式

HRID 221985 の反応式
[Cl:1][C:2]1[N:7]=[C:6]([NH2:8])[C:5](N)=[N:4][CH:3]=1.[CH3:10]CN(C(C)C)C(C)C.O=[C:20]([C:25]1[CH:30]=[CH:29][CH:28]=[CH:27][CH:26]=1)[C:21]([O:23]C)=O>C1COCC1>[Cl:1][C:2]1[CH:3]=[CH:10][C:5]2[C:6]([N:7]=1)=[N:8][C:20]([C:25]1[CH:30]=[CH:29][CH:28]=[CH:27][CH:26]=1)=[C:21]([OH:23])[N:4]=2

参加物

5

反応物 3

HCID 81531DiisopropylethylamineHCID 84835Methyl phenylglyoxalateHCID 707008825-Chloropyrazine-2,3-diamine

生成物 1

HCID 178517175HCID 178517175、化合物

試薬・触媒・溶媒 1

HCID 8028Tetrahydrofuran溶媒

実験手順

A mixture of 6-chloro-2,3-pyrazinediamine (3-1) (15.3 g, 107 mmol), DIPEA (37.2 mL, 213 mmol), and methyl oxo(phenyl)acetate (26.2 g, 160 mmol) in THF (300 mL) was stirred at room temperature for 2 days. The solvent was concentrated under reduced pressure, and EtOAc was added. The resulting solid was collected by filtration to give 6-chloro-3-phenylpyrido[2,3-b]pyrazin-2-ol (3-2) as yellow powder.

後処理

  1. concentrationThe solvent was concentrated under reduced pressure, and EtOAc
  2. additionwas added
  3. filtrationThe resulting solid was collected by filtration

出典と根拠

ORDレコード
ord-808cafb884a848d09ecaa0b7b9a9ce3c
出典データセット
uspto-grants-2012_06
特許番号
US08207169B2

関連ノート

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