Allyl Alcohol → [6-(2-Methoxyphenyl)-2,2-dimethyl-1,2-dihydroquinolin-4-ylmethyl]phenylamine

HRID 25756

反応式

HRID 25756 の反応式
C(OCC1[C:15]2[C:10](=[CH:11][CH:12]=[C:13](C3C=CC=CC=3OC)[CH:14]=2)[NH:9]C(C)(C)C=1)C=C.Br[CH2:27][C:28]1[C:37]2[C:32](=[CH:33][CH:34]=[C:35]([C:38]3[CH:43]=[CH:42][CH:41]=[CH:40][C:39]=3[O:44][CH3:45])[CH:36]=2)[NH:31][C:30]([CH3:47])([CH3:46])[CH:29]=1.C(O)C=C.C[Si]([N-][Si](C)(C)C)(C)C.[Na+]>C1COCC1>[CH3:45][O:44][C:39]1[CH:40]=[CH:41][CH:42]=[CH:43][C:38]=1[C:35]1[CH:36]=[C:37]2[C:32](=[CH:33][CH:34]=1)[NH:31][C:30]([CH3:47])([CH3:46])[CH:29]=[C:28]2[CH2:27][NH:9][C:10]1[CH:15]=[CH:14][CH:13]=[CH:12][CH:11]=1

参加物

6

反応物 4

HCID 7858Allyl AlcoholHCID 2724254Sodium bis(trimethylsilyl)amideHCID 10314903Dihydroquinoline-based ligand, 15HCID 225665354-(Bromomethyl)-6-(2-methoxyphenyl)-2,2-dimethyl-1,2-dihydroquinoline

生成物 1

HCID 10406857[6-(2-Methoxyphenyl)-2,2-dimethyl-1,2-dihydroquinolin-4-ylmethyl]phenylamine

試薬・触媒・溶媒 1

HCID 8028Tetrahydrofuran溶媒

実験手順

4-Allyloxymethyl-6-(2-methoxyphenyl)-2,2-dimethyl-1,2-dihydroquinoline 40 mg of 4-bromomethyl-6-(2-methoxyphenyl)-2,2-dimethyl-1,2-dihydroquinoline, 44 μL of allyl alcohol, and 4 mL of 1 M solution of sodium bis(trimethylsilyl)amide in THF reacted to give 4.5 mg of the title compound as a foam.

出典と根拠

ORDレコード
ord-327afb34ff494ccc98e407e845ba3144
出典データセット
uspto-grants-2005_02
特許番号
US06858627B2

関連ノート

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