Phenol → 4-Phenylbutyric Acid

反応式

[C:1]1([CH:7]2[O:12][C:10](=[O:11])[CH2:9][CH2:8]2)[CH:6]=[CH:5][CH:4]=[CH:3][CH:2]=1.C1(O)C=CC=CC=1.[OH-].[Na+].[OH-].[K+].[H-].[Na+].[Na]>>[C:1]1([CH2:7][CH2:8][CH2:9][C:10]([OH:12])=[O:11])[CH:6]=[CH:5][CH:4]=[CH:3][CH:2]=1

参加物

反応物 6

HCID 996Phenol

HCID 13884gamma-Phenyl-gamma-butyrolactone

HCID 14797Potassium Hydroxide

HCID 14798Sodium Hydroxide

HCID 24758Sodium hydride

HCID 5360545Sodium

生成物 1

HCID 47754-Phenylbutyric Acid

実験手順

For example, a known compound, γ-phenyl-γ-butyrolactone having a melting point of 36° C. to 37° C. is reacted with a phenol derivative having the general formula: ##STR9## wherein R2 represents a hydrogen atom or an alkyl group having 1 to 3 carbon atoms in the presence of a base such as sodium alkoxide, potassium alkoxide, sodium hydroxide, potassium hydroxide, sodium hydride, or sodium metal to form a 4-phenyl butyric acid derivative having the general formula: ##STR10## wherein R2 is the same as defined above,