3-Methoxyphenol → alpha-Hydroxy-beta-(3-Methoxyphenoxy)-N-(1-Methylethyl)Benzenepropanamide

HRID 435495ノート

反応式

HRID 435495 の反応式
[CH3:1][CH:2]([NH:4][C:5]([CH:7]1[CH:9]([C:10]2[CH:15]=[CH:14][CH:13]=[CH:12][CH:11]=2)[O:8]1)=[O:6])[CH3:3].[CH3:16][O:17][C:18]1[CH:19]=[C:20](O)[CH:21]=[CH:22][CH:23]=1.[H-].[Na+].C1OCCOCCOCCOCCOCC[O:29]C1>C(#N)C>[OH:29][CH:7]([CH:9]([O:8][C:22]1[CH:21]=[CH:20][CH:19]=[C:18]([O:17][CH3:16])[CH:23]=1)[C:10]1[CH:11]=[CH:12][CH:13]=[CH:14][CH:15]=1)[C:5]([NH:4][CH:2]([CH3:1])[CH3:3])=[O:6]

参加物

6

反応物 4

HCID 90073-MethoxyphenolHCID 24758Sodium hydrideHCID 2855718-Crown-6HCID 13041334N-(1-methylethyl)-3-phenyl-2-oxiranecarboxamide

生成物 1

HCID 13041339alpha-Hydroxy-beta-(3-Methoxyphenoxy)-N-(1-Methylethyl)Benzenepropanamide

試薬・触媒・溶媒 1

HCID 6342Acetonitrile溶媒

実験手順

This compound was prepared from N-(1-methylethyl)-3-phenyl-2-oxiranecarboxamide (10.3 g.), m-methoxyphenol (6.2 g.), sodium hydride (50% oil dispersion, 2.4 g.), 18-crown-6 (1.5 g.) and acetonitrile (500 ml.) as described in Example 12. The crude product (m.p. 118°-120°, yield 2.6 g.) was then recrystallized from ether with a small amount of tetrahydrofuran, giving 2.3 g. of the pure product, m.p. 132°-133°.

後処理

  1. customThe crude product (m.p. 118°-120°, yield 2.6 g.) was then recrystallized from ether with a small amount of tetrahydrofuran
  2. customgiving 2.3 g

出典と根拠

ORDレコード
ord-a93e2cdd291a4405bdf8eab496f6903a
出典データセット
uspto-grants-1983_08
特許番号
US04401832

反応ノート

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