2,6-Lutidine → 2,6-Dimethylpyridine N-oxide

HRID 446813

反応式

HRID 446813 の反応式
[CH3:1][C:2]1[CH:7]=[CH:6][CH:5]=[C:4]([CH3:8])[N:3]=1.C1C=C(Cl)C=C(C(OO)=[O:17])C=1>C(Cl)(Cl)Cl>[CH3:1][C:2]1[CH:7]=[CH:6][CH:5]=[C:4]([CH3:8])[N+:3]=1[O-:17]

参加物

4

反応物 2

HCID 79372,6-LutidineHCID 70297m-Chloroperbenzoic acid

生成物 1

HCID 140832,6-Dimethylpyridine N-oxide収率 88.4%

試薬・触媒・溶媒 1

HCID 6212Chloroform溶媒

実験手順

To a 0° C. solution of 2,6-dimethylpyridine (1.0 g, 0.009 mol) in CHCl3 (25 mL) was added mCPBA (3.17 g, 0.01 mol). The reaction mixture was then stirred for 12 h at RT, quenched with a saturated Na2CO3 solution. The organic layer was separated, dried over Na2SO4 and concentrated in vacuo to afford 2,6-dimethylpyridine 1-oxide (980 mg, 85%) as a solid.

後処理

  1. customquenched with a saturated Na2CO3 solution
  2. customThe organic layer was separated
  3. dry with materialdried over Na2SO4
  4. concentrationconcentrated in vacuo

出典と根拠

ORDレコード
ord-5694c3e4dc404594a53163c478a732f0
出典データセット
uspto-grants-2013_07
特許番号
US08481534B2

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