Trifluoroacetic acid → 5,7-dichloro-4-phenyl-1,2,3,4-tetrahydroquinoline-2-carboxylic Acid

HRID 47370ノート

反応式

HRID 47370 の反応式
[Cl:1][C:2]1[CH:3]=[C:4]([CH:6]=[C:7]([Cl:9])[CH:8]=1)[NH2:5].[CH2:10]([C:12](=O)[C:13]([O-:15])=[O:14])[CH3:11].C=C[C:19]1[CH:24]=[CH:23][CH:22]=[CH:21][CH:20]=1.FC(F)(F)C(O)=O.[OH-].[Na+]>C(#N)C.C(O)C>[Cl:1][C:2]1[CH:8]=[C:7]([Cl:9])[CH:6]=[C:4]2[C:3]=1[CH:11]([C:19]1[CH:24]=[CH:23][CH:22]=[CH:21][CH:20]=1)[CH2:10][CH:12]([C:13]([OH:15])=[O:14])[NH:5]2

参加物

8

反応物 5

HCID 6422Trifluoroacetic acidHCID 7501StyreneHCID 122813,5-DichloroanilineHCID 14798Sodium HydroxideHCID 35932772-Ketobutyrate

生成物 1

HCID 99231615,7-dichloro-4-phenyl-1,2,3,4-tetrahydroquinoline-2-carboxylic Acid

試薬・触媒・溶媒 2

HCID 702Ethanol溶媒HCID 6342Acetonitrile溶媒

実験手順

Compound 15 was prepared by the basic process from 5.0 mmol 3,5-dichloroaniline, 5.5 mmol ethylglyoxalate solution (50% toluene), 15.0 mmol styrene and 5.0 mmol trifluoroacetic acid in 30.0 ml acetonitrile. Subsequent saponification was carried out using 1.0 ml of sodium hydroxide solution (6N water) in 20.0 ml of ethanol.

出典と根拠

ORDレコード
ord-d3e2222c3045443591698a2b7c600b99
出典データセット
uspto-grants-2004_03
特許番号
US06699877B2

反応ノート

読み込み中…