Formaldehyde → (2S)-2-(4-Methoxybenzylthiomethyl)-1-methylpyrrolidine

HRID 5108

反応式

HRID 5108 の反応式
[CH3:1][O:2][C:3]1[CH:16]=[CH:15][C:6]([CH2:7][S:8][CH2:9][C@@H:10]2[CH2:14][CH2:13][CH2:12][NH:11]2)=[CH:5][CH:4]=1.C=O.[C:19]([BH3-])#N.[Na+]>C(#N)C>[CH3:1][O:2][C:3]1[CH:4]=[CH:5][C:6]([CH2:7][S:8][CH2:9][C@@H:10]2[CH2:14][CH2:13][CH2:12][N:11]2[CH3:19])=[CH:15][CH:16]=1

参加物

5

反応物 3

HCID 712FormaldehydeHCID 5003444Sodium cyanoborohydrideHCID 57043207(2S)-2-(4-methoxybenzylthiomethyl)pyrrolidine

生成物 1

HCID 57048351(2S)-2-(4-Methoxybenzylthiomethyl)-1-methylpyrrolidine収率 41.7%

試薬・触媒・溶媒 1

HCID 6342Acetonitrile溶媒

実験手順

The procedure described in Preparation 5-(4) was repeated, but using 2 g of (2S)-2-(4-methoxybenzylthiomethyl)pyrrolidine, 35% formalin and 848 mg of sodium cyanoborohydride in the presence of 44 ml of acetonitrile, to afford 883 mg of the title compound as an oil.

後処理

  1. customThe procedure described in Preparation 5-(4)

出典と根拠

ORDレコード
ord-1fc826cd6595419badb8308649438ba2
出典データセット
uspto-grants-1993_09
特許番号
US05242914

関連ノート

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