Toluene → 1-Pyrrolidineacetic acid, ethyl ester
反応式
[NH:1]1[CH2:5][CH2:4][CH2:3][CH2:2]1.Br[CH2:7][C:8]([O:10][CH2:11][CH3:12])=[O:9].C1(C)C=CC=CC=1>O1CCCC1>[N:1]1([CH2:7][C:8]([O:10][CH2:11][CH3:12])=[O:9])[CH2:5][CH2:4][CH2:3][CH2:2]1参加物
5
実験手順
To an ice bath-cooled solution of 213.4 g (3 mol) of pyrrolidine in 450 mL of tetrahydrofuran was added dropwise over about 2 hours 250.5 g (1.5 mol) of ethyl bromoacetate, maintaining the temperature below 30° C. To this solution was added 150 mL of toluene to precipitate pyrrolidinium bromide, which was separated by filtration. The filtrate was evaporated under vacuum to provide a residue of about 241 g of ethyl 1-pyrrolinidineacetate.
後処理
- temperaturemaintaining the temperature below 30° C
- customto precipitate pyrrolidinium bromide, which
- customwas separated by filtration
- customThe filtrate was evaporated under vacuum
- customto provide a residue of about 241 g of ethyl 1-pyrrolinidineacetate
出典と根拠
- ORDレコード
- ord-e8381d73f4f9423dbff70d4f1bb4f249
- 出典データセット
- uspto-grants-1993_09
- 特許番号
- US05244997
反応ノート
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