Hydrochloric Acid → Barbituric Acid
反応式
N1C=CC=C1.[K].ICCCC.[NH:12]1[C:20](=[O:21])[C:18](=O)[C:16](=[O:17])[NH:15][C:13]1=[O:14].Cl>C(O)C.O1CCCC1>[NH:12]1[C:20](=[O:21])[CH2:18][C:16](=[O:17])[NH:15][C:13]1=[O:14]参加物
7
実験手順
Potassium pyrrole (3.0 g., 0.03 mole), 1-iodobutane (9.2 g., 0.05 moles) and 10 ml. of tetrahydrofuran were combined and refluxed for 1.5 hours by which time the reaction mixture had become a thick mass. The reaction mixture was diluted with 30 ml. of water and extracted with 35 ml. of ether. The ether was backwashed with water, then added to a solution of anhydrous alloxan (4.8 g., 0.03 mole) obtained by heating in 50 ml. of ethanol. The ether was distilled away, 6N hydrochloric acid (5 ml., 0.03 mole) was added, and the mixture refluxed for 3 minutes, cooled, evaporated to a gum, and triturated with water to afford title product [5.1 g.; m.p. 135 (dec); m/e 265].
後処理
- temperaturerefluxed for 1.5 hours by which time the reaction mixture
- additionThe reaction mixture was diluted with 30 ml
- extractionof water and extracted with 35 ml
- customobtained
- temperatureby heating in 50 ml
- distillationThe ether was distilled away
- temperaturethe mixture refluxed for 3 minutes
- temperaturecooled
- customevaporated to a gum
- customtriturated with water
出典と根拠
- ORDレコード
- ord-fd3679523c564aca9f8f87d8fbc6713d
- 出典データセット
- uspto-grants-1988_06
- 特許番号
- US04753956
反応ノート
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