反応式
[C:1]([NH:4][C:5]1[CH:13]=[CH:12][C:8]([C:9]([OH:11])=O)=[CH:7][CH:6]=1)(=[O:3])[CH3:2].O1CCCC1.C(OC(Cl)=O)C(C)C.[CH:27]1[C:32]([NH2:33])=[CH:31][CH:30]=[C:29]([OH:34])[CH:28]=1>O.N1C=CC=CC=1.C(N(CC)CC)C>[C:1]([NH:4][C:5]1[CH:6]=[CH:7][C:8]([C:9]([NH:33][C:32]2[CH:27]=[CH:28][C:29]([OH:34])=[CH:30][CH:31]=2)=[O:11])=[CH:12][CH:13]=1)(=[O:3])[CH3:2]参加物
8
実験手順
A solution of p-acetamidobenzoic acid (12.5 g.) in 250 ml. of tetrahydrofuran is treated with triethylamine (11.1 ml.). The mixture is then treated with isobutylchloroformate (10.4 ml.) and, after 5 min. at about 25° C., with p-aminophenol (13.3 g.) in 80 ml. of dry pyridine. After 40 min. the crude product is obtained by addition of 2 liters of water. The product is recrystallized from 500 ml. of hot methanol by dilution with 300 ml. of water as white crystals, 5.9 g., m.p. 275.0°-277.0° C.
出典と根拠
- ORDレコード
- ord-293fe4c4febd491faf717d9bd6c6b30c
- 出典データセット
- uspto-grants-1977_03
- 特許番号
- US04010172
関連ノート
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