Hydrochloric Acid → 3-[N'-formyl-N'-(3-hydroxypropyl)amino]-N,N,N-trimethyl-1-propanaminium chloride
反応式
Cl.[Cl-].[Cl:3]CCCN(C)CCC[N+](C)(C)C.S(Cl)(Cl)=O.Cl.[Cl-].[OH:22][CH2:23][CH2:24][CH2:25][N:26]([CH3:34])[CH2:27][CH2:28][CH2:29][N+:30]([CH3:33])([CH3:32])[CH3:31].[Br-].C[N+](C)(C)CCCNC.[O:45]1CCC1.Cl.C(N(CCCN)CCCO)=O.IC.C(=O)([O-])[O-].[Na+].[Na+]>>[Cl-:3].[CH:34]([N:26]([CH2:27][CH2:28][CH2:29][N+:30]([CH3:31])([CH3:32])[CH3:33])[CH2:25][CH2:24][CH2:23][OH:22])=[O:45]参加物
反応物 9
HCID 313Hydrochloric Acid2 回
HCID 6328Methyl iodide
HCID 10340Sodium Carbonate
HCID 10423Oxetane
HCID 24386Thionyl Chloride
HCID 213163673-[N-(3-hydroxypropyl)methylamino]-N,N,N-trimethylpropan-1-aminium chloride hydrochloride2 回
HCID 21444211N,N,N-Trimethyl-3-(methylamino)propan-1-aminium bromide
HCID 233475753-[N-(3-chloropropyl)methylamino]-N,N,N-trimethyl-propan-1-aminium chloride
HCID 157229452N-(3-aminopropyl)-N-(3-hydroxypropyl)formamide;hydrochloride生成物 1
実験手順
The hydrochloride of 3-[N-(3-chloropropyl)methylamino]-N,N,N-trimethyl-propan-1-aminium chloride has been prepared by reacting thionyl chloride with 3-[N-(3-hydroxypropyl)methylamino]-N,N,N-trimethylpropan-1-aminium chloride hydrochloride. This 3-[N-(3-hydroxypropyl)methylamino]-N,N,N-trimethylpropan-1-aminium chloride hydrochloride has been prepared (a) by heating N,N,N-trimethyl-[3-(methylamino)]-1-propanaminium bromide with oxetane, and treating the resulting product with concentrated hydrochloric acid; and (b) by reacting 3-[N'-formyl-N'-(3-hydroxypropyl)amino]-1-propanamine hydrochloride with iodomethane in the presence of sodium carbonate to form 3-[N'-formyl-N'-(3-hydroxypropyl)amino]N,N,N-trimethyl-propan-1-aminium chloride, and reacting the latter with formalin in formic acid followed by concentrated hydrochloric acid.
出典と根拠
- ORDレコード
- ord-51ba6199402540e5a4b94752ef54639b
- 出典データセット
- uspto-grants-1978_06
- 特許番号
- US04093657
反応ノート
読み込み中…