Acetonitrile → Triphenylphosphine

HRID 846246

反応式

HRID 846246 の反応式
O[NH-].[O:3]1[CH2:7][CH2:6]C[CH2:4]1.C(#[N:10])C.[C:11]1([P:17]([C:24]2[CH:29]=[CH:28][CH:27]=[CH:26][CH:25]=2)[C:18]2[CH:23]=[CH:22][CH:21]=[CH:20][CH:19]=2)[CH:16]=[CH:15][CH:14]=[CH:13][CH:12]=1>C(Cl)(Cl)(Cl)Cl.C(Cl)(Cl)Cl>[C:24]1([P:17]([C:11]2[CH:12]=[CH:13][CH:14]=[CH:15][CH:16]=2)[C:18]2[CH:23]=[CH:22][CH:21]=[CH:20][CH:19]=2)[CH:25]=[CH:26][CH:27]=[CH:28][CH:29]=1.[O:3]1[CH2:7][CH2:6][N:10]=[CH:4]1

参加物

8

反応物 4

HCID 6342AcetonitrileHCID 8028TetrahydrofuranHCID 11776TriphenylphosphineHCID 178514248HCID 178514248、化合物

生成物 2

HCID 11776TriphenylphosphineHCID 68157Oxazoline

試薬・触媒・溶媒 2

HCID 5943Carbon Tetrachloride溶媒HCID 6212Chloroform溶媒

実験手順

Hydroxyamide IX is then subjected to cyclodehydration in an inert organic solvent (e.g., tetrahydrofuran, acetonitrile or chloroform) under an inert atmosphere (e.g., argon) with triphenylphosphine (employing a molar ratio of V:triphenylphosphine of from about 0.8:1 to about 1:1) and carbon tetrachloride in the presence of an amine base (e.g., triethylamine or diisopropylethylamine) to form oxazoline ##STR23##

出典と根拠

ORDレコード
ord-9faeadff4ef440cda5bbff849c7c2f54
出典データセット
uspto-grants-1992_08
特許番号
US05135939

関連ノート

読み込み中…