Calcium Acetate → Acrylamide

HRID 859824

反応式

HRID 859824 の反応式
C([O-])(=[O:3])C.[Ca+2].C([O-])(=[O:8])C.[C:10](#[N:13])[CH:11]=[CH2:12].[C:14](#[N:18])[C:15]([CH3:17])=[CH2:16].[OH:19][CH:20]([CH2:24][CH3:25])[CH2:21][C:22]#[N:23]>O>[C:10]([NH2:13])(=[O:3])[CH:11]=[CH2:12].[C:14]([NH2:18])(=[O:8])[C:15]([CH3:17])=[CH2:16].[OH:19][CH:20]([CH2:24][CH3:25])[CH2:21][C:22]([NH2:23])=[O:3]

参加物

8

反応物 4

HCID 6116Calcium AcetateHCID 7855AcrylonitrileHCID 31368MethacrylonitrileHCID 98554543-hydroxypentanenitrile

生成物 3

HCID 6579AcrylamideHCID 6595MethacrylamideHCID 149797283-Hydroxypentanamide

試薬・触媒・溶媒 1

HCID 962Water溶媒

実験手順

At the completion of the reaction (100% conversion of nitrile), the product mixture was decanted from the biocatalyst beads, and additional distilled, deionized water, 0.2 mL of 0.20 M calcium acetate buffer (pH 7.0, 2.0 mM final calcium ion concentration in reaction mixture) and 10, 20, 40 or 60 mmol of acrylonitrile, methacrylonitrile, or 3-hydroxy-valeronitrile mixed with the reaction heel (immobilized-cell catalyst and remaining product mixture from the first reaction) at 25° C. or 35° C. At the completion of the second reaction, the product mixture was decanted and a third reaction performed as before. The reaction time, product yield for acrylamide, methacrylamide, or 3-hydroxyvaleramide, and the percent recovered biocatalyst activity for each recycle reaction is listed in Table 11 below.

後処理

  1. customthe product mixture was decanted from the biocatalyst beads, and additional distilled
  2. additionmixed with the reaction heel (immobilized-cell catalyst
  3. customfrom the first reaction) at 25° C.
  4. custom35° C
  5. customAt the completion of the second reaction
  6. customthe product mixture was decanted
  7. customa third reaction

出典と根拠

ORDレコード
ord-c07dcbf335074ec9a8f7df812147b5b9
出典データセット
uspto-grants-2006_12
特許番号
US07153663B2

関連ノート

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