Trimethyl orthoformate → Methyl (3-amino-4-fluoro-5-(4-(oxetan-3-yl)piperazin-1-yl)phenyl)(4-methoxybenzyl)carbamate

反応式

[NH2:1][C:2]1[CH:3]=[C:4]([N:15]([CH2:20][C:21]2[CH:26]=[CH:25][C:24]([O:27][CH3:28])=[CH:23][CH:22]=2)[C:16](=[O:19])[O:17][CH3:18])[CH:5]=[C:6]([N:9]2[CH2:14][CH2:13][NH:12][CH2:11][CH2:10]2)[C:7]=1[F:8].[O:29]1[CH2:32][C:31](=O)[CH2:30]1.C(OC)(OC)OC.C([O-])(=O)C.[K+].C([BH3-])#N.[Na+]>CO.O1CCCC1>[NH2:1][C:2]1[CH:3]=[C:4]([N:15]([CH2:20][C:21]2[CH:22]=[CH:23][C:24]([O:27][CH3:28])=[CH:25][CH:26]=2)[C:16](=[O:19])[O:17][CH3:18])[CH:5]=[C:6]([N:9]2[CH2:10][CH2:11][N:12]([CH:31]3[CH2:32][O:29][CH2:30]3)[CH2:13][CH2:14]2)[C:7]=1[F:8]