Ethyl chloroformate → N-(1,1-dimethoxyprop-2-yl)urethane

HRID 974913

反応式

HRID 974913 の反応式
Cl[C:2]([O:4][CH2:5][CH3:6])=[O:3].[CH3:7][O:8][CH:9]([O:13][CH3:14])[CH:10]([NH2:12])[CH3:11].[OH-].[Na+]>C1(C)C=CC=CC=1.O>[CH3:7][O:8][CH:9]([O:13][CH3:14])[CH:10]([NH:12][C:2]([O:4][CH2:5][CH3:6])=[O:3])[CH3:11]

参加物

6

反応物 3

HCID 10928Ethyl chloroformateHCID 14798Sodium HydroxideHCID 936582,2-Dimethoxy-1-methylethylamine

生成物 1

HCID 15069987N-(1,1-dimethoxyprop-2-yl)urethane

試薬・触媒・溶媒 2

HCID 962Water溶媒HCID 1140Toluene溶媒

実験手順

80 g (0.73 mol) of ethyl chloroformate are added dropwise to 86.2 g (0.72 mol) of 2-aminopropionaldehyde dimethyl acetal in 350 ml of toluene and 32 g (0.8 mol) of NaOH in 300 ml of water. The mixture is stirred at room temperature for a further 2 hours, the organic phase is separated off, the aqueous phase is extracted with toluene and the toluene solutions are dried over K2CO3. The solution is concentrated and the residue is distilled.

後処理

  1. customthe organic phase is separated off
  2. extractionthe aqueous phase is extracted with toluene
  3. dry with materialthe toluene solutions are dried over K2CO3
  4. concentrationThe solution is concentrated
  5. distillationthe residue is distilled

出典と根拠

ORDレコード
ord-8168b6ff1ef041fb9cd3b7b6c0230015
出典データセット
uspto-grants-1997_03
特許番号
US05607942

関連ノート

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