Ethyl chloroformate → N-(1,1-dimethoxyprop-2-yl)urethane
反応式
Cl[C:2]([O:4][CH2:5][CH3:6])=[O:3].[CH3:7][O:8][CH:9]([O:13][CH3:14])[CH:10]([NH2:12])[CH3:11].[OH-].[Na+]>C1(C)C=CC=CC=1.O>[CH3:7][O:8][CH:9]([O:13][CH3:14])[CH:10]([NH:12][C:2]([O:4][CH2:5][CH3:6])=[O:3])[CH3:11]参加物
6
実験手順
80 g (0.73 mol) of ethyl chloroformate are added dropwise to 86.2 g (0.72 mol) of 2-aminopropionaldehyde dimethyl acetal in 350 ml of toluene and 32 g (0.8 mol) of NaOH in 300 ml of water. The mixture is stirred at room temperature for a further 2 hours, the organic phase is separated off, the aqueous phase is extracted with toluene and the toluene solutions are dried over K CO2. The solution is concentrated and the residue is distilled.
後処理
- customthe organic phase is separated off
- extractionthe aqueous phase is extracted with toluene
- dry with materialthe toluene solutions are dried over K CO2
- concentrationThe solution is concentrated
- distillationthe residue is distilled
出典と根拠
- ORDレコード
- ord-601fee977f964477af88a7844b7489f2
- 出典データセット
- uspto-grants-1991_02
- 特許番号
- US04990517
反応ノート
読み込み中…