Ethyl chloroformate → N-(1,1-dimethoxyprop-2-yl)urethane

HRID 981102

反応式

HRID 981102 の反応式
Cl[C:2]([O:4][CH2:5][CH3:6])=[O:3].[CH3:7][O:8][CH:9]([O:13][CH3:14])[CH:10]([NH2:12])[CH3:11].[OH-].[Na+]>C1(C)C=CC=CC=1.O>[CH3:7][O:8][CH:9]([O:13][CH3:14])[CH:10]([NH:12][C:2]([O:4][CH2:5][CH3:6])=[O:3])[CH3:11]

参加物

6

反応物 3

HCID 10928Ethyl chloroformateHCID 14798Sodium HydroxideHCID 936582,2-Dimethoxy-1-methylethylamine

生成物 1

HCID 15069987N-(1,1-dimethoxyprop-2-yl)urethane

試薬・触媒・溶媒 2

HCID 962Water溶媒HCID 1140Toluene溶媒

実験手順

80 g (0.73 mol) of ethyl chloroformate are added dropwise to 86.2 g (0.72 mol) of 2-aminopropionaldehyde dimethyl acetal in 350 ml of toluene and 32 g (0.8 mol) of NaOH in 300 ml of water. The mixture is stirred at room temperature for a further 2 hours, the organic phase is separated off, the aqueous phase is extracted with toluene and the toluene solutions are dried over K CO2. The solution is concentrated and the residue is distilled.

後処理

  1. customthe organic phase is separated off
  2. extractionthe aqueous phase is extracted with toluene
  3. dry with materialthe toluene solutions are dried over K CO2
  4. concentrationThe solution is concentrated
  5. distillationthe residue is distilled

出典と根拠

ORDレコード
ord-601fee977f964477af88a7844b7489f2
出典データセット
uspto-grants-1991_02
特許番号
US04990517

関連ノート

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