6-Chloroquinoline → HCID 178422846, 화합물

HRID 1099729

반응식

HRID 1099729 반응식
Cc1ccc2c(cnn2C2CCCCO2)c1B(O)O.Clc1ccc2ncccc2c1>CC#N.CC(=O)[O-].CC(=O)[O-].CC(C)(C)P(C(C)(C)C)C(C)(C)C.CCc1cc(CC)cc(CC)c1.CCc1cccc(CC)c1.CN(C)C=O.Cc1ccccc1.O.[Na+].[OH-].[Pd+2]>Cc1ccc2c(cnn2C2CCCCO2)c1-c1ccc2ncccc2c1

참가 물질

13

반응물 2

HCID 691636-ChloroquinolineHCID 129009568[5-Methyl-1-(oxan-2-yl)-1H-indazol-4-yl]boronic acid

생성물 1

HCID 178422846HCID 178422846, 화합물수율 4.76%

시약·촉매·용매 10

HCID 14798Sodium Hydroxide시약HCID 83681Tris(1,1-dimethylethyl)phosphine촉매HCID 167845palladium(II) acetate촉매HCID 962Water용매2회HCID 1140Toluene용매HCID 6228Dimethylformamide용매HCID 6342Acetonitrile용매HCID 76021,3,5-Triethylbenzene용매HCID 88641,3-Diethylbenzene용매HCID 741954,4'-Bis(1,1-dimethylethyl)-1,1'-biphenyl내부 표준

반응 조건

온도
100 °C

출처 및 근거

ORD 기록
ord-61b2819b15824f1fa131ed1b2ea1dae4
출처 데이터셋
Rapid material-sparing screening of 5760 Suzuki-Miyaura coupling reactions
원본 링크
출처 보기

연결된 노트

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