Bromide ion → (2,6-Dichloro-3-methoxybenzyl)(triphenyl)phosphonium bromide

HRID 11072

반응식

HRID 11072 반응식
[Cl:1][C:2]1[C:7]([O:8][CH3:9])=[CH:6][CH:5]=[C:4]([Cl:10])[C:3]=1[CH2:11]O.[BrH:13].[Br-].[C:15]1([P:21]([C:28]2[CH:33]=[CH:32][CH:31]=[CH:30][CH:29]=2)[C:22]2[CH:27]=[CH:26][CH:25]=[CH:24][CH:23]=2)[CH:20]=[CH:19][CH:18]=[CH:17][CH:16]=1>C(O)(=O)C.C(Cl)Cl.C1C=CC=CC=1>[Br-:13].[Cl:1][C:2]1[C:7]([O:8][CH3:9])=[CH:6][CH:5]=[C:4]([Cl:10])[C:3]=1[CH2:11][P+:21]([C:22]1[CH:23]=[CH:24][CH:25]=[CH:26][CH:27]=1)([C:28]1[CH:33]=[CH:32][CH:31]=[CH:30][CH:29]=1)[C:15]1[CH:16]=[CH:17][CH:18]=[CH:19][CH:20]=1

참가 물질

7

반응물 4

HCID 259Bromide ionHCID 260Hydrogen BromideHCID 11776TriphenylphosphineHCID 21980844(2,6-Dichloro-3-methoxyphenyl)methanol

생성물 1

HCID 87899066(2,6-Dichloro-3-methoxybenzyl)(triphenyl)phosphonium bromide수율 97%

시약·촉매·용매 2

HCID 176Acetic Acid용매HCID 23443464Methane, dichloro-, compd. with benzene (1:1)용매

실험 절차

Bromination of (2,6-dichloro-3-methoxyphenyl)methanol with 30% HBr in acetic acid, followed by reaction of the crude bromide with triphenylphosphine, using the procedure described in example 112, except that the reaction time for the displacement was 36 h, gave the phosphonium salt (526) (97%) as a white solid, mp (CH2Cl2/benzene) 242–244° C. 1H NMR (CDCl3) δ 7.83–7.60 (m, 15H), 7.15 (dd, J=9.1, 0.8 Hz, 1H), 6.88 (dd, J=9.0, 2.4 Hz, 1H), 5.41 (d, J=14.3 Hz, 2H), 3.84 (s, 3H). Found: C, 58.68; H, 4.16. C26H22BrCl2OP requires C, 58.67; H, 4.17.

출처 및 근거

ORD 기록
ord-45cd2ce8b12c4a538ef3a33a64d2aec4
출처 데이터셋
uspto-grants-2006_08
특허 번호
US07094798B1

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