1-Butanol → Benzenepropanol
반응식
[CH2:1]([OH:5])[CH2:2][CH2:3][CH3:4].ClCl.Cl[CH:9](Cl)[CH:10](Cl)Cl.Cl[C:15](Cl)([CH2:18]C)[CH:16]=O>CN(C=O)C.Cl.C(O)C(C)C>[C:4]1([CH2:3][CH2:2][CH2:1][OH:5])[CH:10]=[CH:9][CH:18]=[CH:15][CH:16]=1참가 물질
7
실험 절차
n-Butanol and Cl2 were added concurrently to a 100 ml, four necked, round bottomed flask containing ~10 g of DMF/HCl catalyst and 25 ml of 1,1,2,2-tetrachloroethane. The temperature was maintained between 50° and 55° C. by controlling the rates of the addition. Upon completion of the addition, the reaction mixture was shown to contain mainly the product 2,2-dichlorobutyraldehyde by GC and NMR analysis. Similar results were obtained with isobutanol and 3-phenylpropanol. Analysis was in agreement with authentic products by GC, IR and NMR.
후처리
- temperatureThe temperature was maintained between 50° and 55° C.
- additionthe rates of the addition
- additionUpon completion of the addition
- customSimilar results
출처 및 근거
- ORD 기록
- ord-58577cdad3b14dbdae74e7181a87f133
- 출처 데이터셋
- uspto-grants-1984_12
- 특허 번호
- US04486608
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