Dimethyl Sulfate → tert-Butylanisole

HRID 1174078노트

반응식

HRID 1174078 반응식
COS([O:6][CH3:7])(=O)=O.[C:8]([C:12]1[CH:17]=[CH:16][CH:15]=[CH:14][C:13]=1O)([CH3:11])([CH3:10])[CH3:9].[OH-].[Na+]>[Br-].C([N+](CCCC)(CCCC)CCCC)CCC.C(Cl)Cl>[C:8]([C:12]1[CH:17]=[CH:16][CH:15]=[CH:14][C:13]=1[O:6][CH3:7])([CH3:11])([CH3:10])[CH3:9]

참가 물질

6

반응물 3

HCID 6497Dimethyl SulfateHCID 69232-Tert-ButylphenolHCID 14798Sodium Hydroxide

생성물 1

HCID 270626tert-Butylanisole

시약·촉매·용매 2

HCID 74236Tetrabutylammonium Bromide촉매HCID 6344Dichloromethane용매

실험 절차

Dimethylsulfate (56.7 g, 0.45 mol) was added at room temperature to a well-stirred mixture of 2-tert-butylphenol (45 g, 0.3 mol), CH2Cl2 (200 ml), 40% aq. NaOH (200 ml) and tetrabutylammonium bromide (1 g). After 16 h of stirring, the organic phase was separated, washed with H2O, dried over MgSO4, evaporated and distilled at 110-112° C./10 Torr. Yield 35 g (71%).

후처리

  1. customthe organic phase was separated
  2. washwashed with H2O
  3. dry with materialdried over MgSO4
  4. customevaporated
  5. distillationdistilled at 110-112° C./10 Torr

출처 및 근거

ORD 기록
ord-7b013c4d5af44a8aa3faa5907fc81757
출처 데이터셋
uspto-grants-2010_11
특허 번호
US07834205B2

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