Dimethyl Sulfoxide → HCID 18507323, 화합물

HRID 1356081노트

반응식

HRID 1356081 반응식
C(O[C:4]([C:6]1[O:10][N:9]=[CH:8][CH:7]=1)=O)C.[CH2:11]([Li])[CH2:12][CH2:13]C.[H-].[Na+].CI.[N+:20]([O-])(O)=O.[NH2:24][C:25]([NH2:27])=[NH:26].C[S:29]([CH3:31])=O>C1COCC1.CN(C=O)C.C(N(CC)CC)C.C(=S)=S.C(#N)C>[NH2:26][C:25]1[N:27]=[C:4]([C:6]2[O:10][N:9]=[CH:8][CH:7]=2)[C:12]([C:13]#[N:20])=[C:11]([S:29][CH3:31])[N:24]=1

참가 물질

12

반응물 6

HCID 679Dimethyl SulfoxideHCID 6328Methyl iodideHCID 10481Guanidine NitrateHCID 24758Sodium hydrideHCID 10701915Ethyl 1,2-oxazole-5-carboxylateHCID 178418339Butyllithium

생성물 1

HCID 18507323HCID 18507323, 화합물

시약·촉매·용매 5

HCID 6228Dimethylformamide용매HCID 6342Acetonitrile용매HCID 6348Carbon Disulfide용매HCID 8028Tetrahydrofuran용매HCID 8471Triethylamine용매

실험 절차

From isoxazole-5-carboxylic acid ethyl ester with acetonitrile and butyllithium in THF. Then treatment with sodium hydride, carbon disulphide and methyl iodide in DMSO. Then treatment with guanidine nitrate and triethylamine in DMF. EI-MS m/e (%): 233 (M+, 45), 206 ([M—HCN]+, 100), 151 (33).

출처 및 근거

ORD 기록
ord-bb8269a6dd3d47bcbaf68dcba639993c
출처 데이터셋
uspto-grants-2003_07
특허 번호
US06586441B2

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