Hydrochloric Acid → 1-Methyl-4,6-dichloroisatin

HRID 1369122

반응식

HRID 1369122 반응식
[H-].[Na+].[Cl:3][C:4]1[CH:12]=[C:11]([Cl:13])[CH:10]=[C:9]2[C:5]=1[C:6](=[O:15])[C:7](=[O:14])[NH:8]2.I[CH3:17].Cl>C1COCC1>[CH3:17][N:8]1[C:9]2[C:5](=[C:4]([Cl:3])[CH:12]=[C:11]([Cl:13])[CH:10]=2)[C:6](=[O:15])[C:7]1=[O:14]

참가 물질

6

반응물 4

HCID 313Hydrochloric AcidHCID 6328Methyl iodideHCID 24758Sodium hydrideHCID 2519084,6-Dichloroisatin

생성물 1

HCID 185185371-Methyl-4,6-dichloroisatin수율 84%

시약·촉매·용매 1

HCID 8028Tetrahydrofuran용매

실험 절차

A mixture of 60% NaH (20.5 mg), 4,6-dichloroisatin (947 mg), and iodomethane (0.328 mL) in THF (20 mL) were stirred overnight at room temperature, poured into 1 N hydrochloric acid, and extracted with ethyl acetate. The extracts were washed with sat. aqueous NaCl, dried over MgSO4, and concentrated. The residue was washed with hexane to give the title compound (849 mg, 84%).

후처리

  1. extractionextracted with ethyl acetate
  2. washThe extracts were washed with sat. aqueous NaCl
  3. dry with materialdried over MgSO4
  4. concentrationconcentrated
  5. washThe residue was washed with hexane

출처 및 근거

ORD 기록
ord-ead5a8352e254e4fac6704b9d6f66aa2
출처 데이터셋
uspto-grants-2003_06
특허 번호
US06576656B1

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