Methyl iodide → 4-(diphenylmethyl)-1-N-(n-dodecyliminomethyl)piperidine fumarate

HRID 1413950노트

반응식

HRID 1413950 반응식
[C:1]1([CH:7]([C:16]2[CH:21]=[CH:20][CH:19]=[CH:18][CH:17]=2)[CH:8]2[CH2:13][CH2:12][N:11]([CH:14]=S)[CH2:10][CH2:9]2)[CH:6]=[CH:5][CH:4]=[CH:3][CH:2]=1.CI.[CH2:24]([NH2:36])[CH2:25][CH2:26][CH2:27][CH2:28][CH2:29][CH2:30][CH2:31][CH2:32][CH2:33][CH2:34][CH3:35].[OH-].[Na+].[C:39]([O-:46])(=[O:45])/[CH:40]=[CH:41]/[C:42]([O-:44])=[O:43]>C(Cl)(Cl)Cl>[C:39]([OH:46])(=[O:45])/[CH:40]=[CH:41]/[C:42]([OH:44])=[O:43].[C:1]1([CH:7]([C:16]2[CH:21]=[CH:20][CH:19]=[CH:18][CH:17]=2)[CH:8]2[CH2:13][CH2:12][N:11]([CH:14]=[N:36][CH2:24][CH2:25][CH2:26][CH2:27][CH2:28][CH2:29][CH2:30][CH2:31][CH2:32][CH2:33][CH2:34][CH3:35])[CH2:10][CH2:9]2)[CH:6]=[CH:5][CH:4]=[CH:3][CH:2]=1

참가 물질

7

반응물 5

HCID 6328Methyl iodideHCID 13583DodecylamineHCID 14798Sodium HydroxideHCID 5460307FumarateHCID 130978784-(Diphenylmethyl)-1-piperidinecarbothioaldehyde

생성물 1

HCID 202912264-(diphenylmethyl)-1-N-(n-dodecyliminomethyl)piperidine fumarate

시약·촉매·용매 1

HCID 6212Chloroform용매

실험 절차

A solution of 5.54 g (0.019 mole) of 4-(diphenylmethyl)-1-piperidinecarbothioaldehyde in 20 ml of chloroform was treated with 2.65 g (1.16 ml, 0.019 mole) of methyl iodide and refluxed for one hour. The resulting solution was treated with 3.49 g (0.019 mole) of n-dodecylamine, refluxed one and one half hours, cooled, treated with aqueous sodium hydroxide and the organic layer separated. After drying, evaporation yielded an oil which was converted to the fumarate to yield 4-(diphenylmethyl)-1-N-(n-dodecyliminomethyl)piperidine fumarate; m.p. 143°-145.5° C.

후처리

  1. temperaturerefluxed for one hour
  2. temperaturerefluxed one and one half hours
  3. temperaturecooled
  4. customthe organic layer separated
  5. customAfter drying
  6. customevaporation
  7. customyielded an oil which

출처 및 근거

ORD 기록
ord-0d6cffce02a649ea93587ddd40a8a621
출처 데이터셋
uspto-grants-1981_02
특허 번호
US04251655

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