Hydrogen Bromide → 1-(Chloromethyl)adamantane

HRID 1414200

반응식

HRID 1414200 반응식
[C:1]12([CH2:11]O)[CH2:10][CH:5]3[CH2:6][CH:7]([CH2:9][CH:3]([CH2:4]3)[CH2:2]1)[CH2:8]2.C12(CBr)CC3CC(CC(C3)C1)C2.Br.[ClH:26]>[Br-].[Zn+2].[Br-].[Cl-].[Zn+2].[Cl-]>[C:1]12([CH2:11][Cl:26])[CH2:10][CH:5]3[CH2:6][CH:7]([CH2:9][CH:3]([CH2:4]3)[CH2:2]1)[CH2:8]2

참가 물질

7

반응물 4

HCID 260Hydrogen BromideHCID 313Hydrochloric AcidHCID 64556Tricyclo(3.3.1.1'3,7)dec-1-ylmethanol2회HCID 14163041-(Bromomethyl)adamantane

생성물 1

HCID 21039691-(Chloromethyl)adamantane수율 91%

시약·촉매·용매 2

HCID 3007855Zincchloride촉매HCID 10421208Zinc bromide촉매

실험 절차

Chlorination reaction of 1-adamantyl methylalcohol which was obtained by the same method described in (1) was carried out under the same conditions for the bromination reaction shown in (2) except that zinc bromide and hydrobromic acid were replaced by zinc chloride and hydrochloric acid respectively. The product was purified by recrystallized from methanol. Melting point of 1-adamantyl methyl chloride thus obtained was 32°-34° C and the yield was 91%.

후처리

  1. customwas obtained by the same method
  2. customwas carried out under the same conditions for the bromination reaction
  3. customThe product was purified
  4. customby recrystallized from methanol

출처 및 근거

ORD 기록
ord-fbbd2f48596345ff98bd1e3f739e32b8
출처 데이터셋
uspto-grants-1977_01
특허 번호
US04001223

연결된 노트

불러오는 중…