Hydrochloric Acid → 1,2-Diamino-4-(pyrimidin-2-ylthio)benzene

HRID 1415526

반응식

HRID 1415526 반응식
[NH2:1][C:2]1[CH:7]=[C:6]([S:8][C:9]2[N:14]=[CH:13][CH:12]=[CH:11][N:10]=2)[CH:5]=[CH:4][C:3]=1[N+:15]([O-])=O.Cl.C(=O)(O)[O-].[K+]>C(Cl)(Cl)Cl>[NH2:15][C:3]1[CH:4]=[CH:5][C:6]([S:8][C:9]2[N:10]=[CH:11][CH:12]=[CH:13][N:14]=2)=[CH:7][C:2]=1[NH2:1]

참가 물질

5

반응물 3

HCID 313Hydrochloric AcidHCID 516893Potassium BicarbonateHCID 214827752-Nitro-5-[(pyrimidin-2-yl)sulfanyl]aniline

생성물 1

HCID 214827791,2-Diamino-4-(pyrimidin-2-ylthio)benzene

시약·촉매·용매 1

HCID 6212Chloroform용매

실험 절차

3.5 G. of 2-amino-1-nitro-4-(pyrimidin-2-ylthio)benzene is treated with 16 g. stannous chloride in 16 ml. concentrated hydrochloric acid on the steam bath for 30 minutes. The mixture is cooled, treated with an excess of potassium bicarbonate, chloroform, and filtered. The chloroform layer is dried and stripped yielding 1,2-diamino-4-(pyrimidin-2-ylthio)benzene which may be recrystallized from benzene.

후처리

  1. temperatureThe mixture is cooled
  2. filtrationfiltered
  3. dry with materialThe chloroform layer is dried

출처 및 근거

ORD 기록
ord-9e608459653b47e88ce7dbe770e09bbd
출처 데이터셋
uspto-grants-1977_01
특허 번호
US04005202

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