Hydrochloric Acid → (2,4-Dimethoxyphenyl)(4-methoxyphenyl)methanone

HRID 1683143

반응식

HRID 1683143 반응식
[CH3:1][O:2][C:3]1[CH:8]=[CH:7][CH:6]=[C:5]([O:9][CH3:10])[CH:4]=1.[C:11](Cl)(=[O:20])[C:12]1[CH:17]=[CH:16][C:15]([O:18][CH3:19])=[CH:14][CH:13]=1.[Cl-].[Al+3].[Cl-].[Cl-].Cl>C(Cl)Cl>[CH3:1][O:2][C:3]1[CH:4]=[C:5]([O:9][CH3:10])[CH:6]=[CH:7][C:8]=1[C:11]([C:12]1[CH:17]=[CH:16][C:15]([O:18][CH3:19])=[CH:14][CH:13]=1)=[O:20]

참가 물질

6

반응물 4

HCID 313Hydrochloric AcidHCID 7477p-Anisoyl chlorideHCID 90251,3-DimethoxybenzeneHCID 6451240Aluminum(III) Chloride

생성물 1

HCID 254174(2,4-Dimethoxyphenyl)(4-methoxyphenyl)methanone

시약·촉매·용매 1

HCID 6344Dichloromethane용매

실험 절차

1,3-Dimethoxybenzene (13.8 grams, 0.1 mole) and p-anisoyl chloride (17 grams, 0.1 mole) were dissolved in 200 milliliters of methylene chloride and stirred at room temperature. Anhydrous aluminum chloride (15 grams) was added slowly to the reaction mixture over a period of 15 minutes with stirring. After stirring an additional 15 minutes, the contents of the flask were carefully poured into 200 milliliters of a mixture of ice and dilute hydrochloric acid. The organic fraction was separated and washed with water. The solvent was removed on a rotary evaporator leaving an oily product that solidified on standing. This solid was broken-up, washed with two 50 milliliter portions of pentane, and dried, yielding 2,4,4'-trimethoxybenzophenone.

후처리

  1. stirringwith stirring
  2. stirringAfter stirring an additional 15 minutes
  3. customThe organic fraction was separated
  4. washwashed with water
  5. customThe solvent was removed on a rotary evaporator
  6. customleaving an oily product that
  7. washwashed with two 50 milliliter portions of pentane
  8. customdried

출처 및 근거

ORD 기록
ord-b789686693d84967a5e432cb57c5482c
출처 데이터셋
uspto-grants-1997_06
특허 번호
US05637262

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