Methane → Dl-Phenylalanine

HRID 1905819

반응식

HRID 1905819 반응식
[CH2:1]([CH:8]1[NH:12]C(=O)N[C:9]1=[O:14])[C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][CH:3]=1.[OH-:15].[Na+].C.Cl>>[NH2:12][CH:8]([C:9]([OH:14])=[O:15])[CH2:1][C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][CH:3]=1

참가 물질

5

반응물 4

HCID 297MethaneHCID 313Hydrochloric AcidHCID 14798Sodium HydroxideHCID 735655-(Phenylmethyl)-2,4-imidazolidinedione

생성물 1

HCID 994Dl-Phenylalanine수율 72%

실험 절차

95.1 g (0.5 mole) of 5-benzyl-hydantoin are heated to boiling in 350 ml of a 20% sodium hydroxide solution for 30 hours. The reaction mixture is clarified with activated charcoal and acidified with concentrated hydrochloric acid (pH 2). The precipitate (hydrantoinic acid) is filtered off and the phenyl alanine is precipitated from the filtrate as described in Example 11. Thus 59.5 g of the dry desired compound are obtained, yield 72%. Purity: 97.5% (according to HPLC).

후처리

  1. filtrationThe precipitate (hydrantoinic acid) is filtered off
  2. customthe phenyl alanine is precipitated from the filtrate
  3. dry with materialThus 59.5 g of the dry desired compound
  4. customare obtained

출처 및 근거

ORD 기록
ord-6e1f3bdc80a248e58d49025324ccd378
출처 데이터셋
uspto-grants-1987_03
특허 번호
US04647694

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