1-Bromo-3-methylbutane → 7-(3-Methylbutyl)-3-methylxanthine

HRID 2034

반응식

HRID 2034 반응식
[CH3:1][N:2]1[C:10]2[N:9]=[CH:8][NH:7][C:6]=2[C:5](=[O:11])[NH:4][C:3]1=[O:12].[H-].[Na+].[H][H].Br[CH2:18][CH2:19][CH:20]([CH3:22])[CH3:21]>CN(C=O)C.O>[CH3:21][CH:20]([CH3:22])[CH2:19][CH2:18][N:7]1[C:6]2[C:5](=[O:11])[NH:4][C:3](=[O:12])[N:2]([CH3:1])[C:10]=2[N:9]=[CH:8]1

참가 물질

7

반응물 4

HCID 78911-Bromo-3-methylbutaneHCID 24758Sodium hydrideHCID 706393-MethylxanthineHCID 178418361HCID 178418361, 화합물

생성물 1

HCID 196891447-(3-Methylbutyl)-3-methylxanthine

시약·촉매·용매 2

HCID 962Water용매HCID 6228Dimethylformamide용매

반응 조건

온도
60 °C

실험 절차

100 g (0.602 mol) of 3-methylxanthine, dissolved in 1200 ml of DMF, were slowly treated with 16 g (0.66 mol) of sodium hydride. The solution was heated to 60° C. and, when the evolution of hydrogen was at an end, treated with 109 g (0.66 mol) of 1-bromo-3-methylbutane. The reaction mixture was stirred at 100° C. for 12 hours and introduced into 2000 ml of water. The precipitate was filtered off with suction, washed with water and dried to constant weight.

후처리

  1. filtrationThe precipitate was filtered off with suction
  2. washwashed with water
  3. customdried to constant weight

출처 및 근거

ORD 기록
ord-53dbbec3515e46f1bf52497ce7ab8115
출처 데이터셋
uspto-grants-1998_03
특허 번호
US05728686

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