Sulfuric Acid → Canthaxanthin

HRID 2057737

반응식

HRID 2057737 반응식
Cl([O-])(=O)=O.[Na+].[I-].[Na+].[CH3:8][C:9]1[CH:14]([OH:15])[CH2:13][CH2:12][C:11]([CH3:17])([CH3:16])[C:10]=1/[CH:18]=[CH:19]/[C:20](/[CH3:49])=[CH:21]/[CH:22]=[CH:23]/[C:24](/[CH3:48])=[CH:25]/[CH:26]=[CH:27]/[CH:28]=[C:29](\[CH3:47])/[CH:30]=[CH:31]/[CH:32]=[C:33](\[CH3:46])/[CH:34]=[CH:35]/[C:36]1[C:41]([CH3:43])([CH3:42])[CH2:40][CH2:39][CH:38]([OH:44])[C:37]=1[CH3:45].S(=O)(=O)(O)O.C(=O)([O-])[O-].[Na+].[Na+]>O.C(Cl)(Cl)Cl>[CH3:45][C:37]1[C:38](=[O:44])[CH2:39][CH2:40][C:41]([CH3:42])([CH3:43])[C:36]=1/[CH:35]=[CH:34]/[C:33](/[CH3:46])=[CH:32]/[CH:31]=[CH:30]/[C:29](/[CH3:47])=[CH:28]/[CH:27]=[CH:26]/[CH:25]=[C:24](\[CH3:48])/[CH:23]=[CH:22]/[CH:21]=[C:20](\[CH3:49])/[CH:19]=[CH:18]/[C:10]1[C:11]([CH3:17])([CH3:16])[CH2:12][CH2:13][C:14](=[O:15])[C:9]=1[CH3:8]

참가 물질

8

반응물 5

HCID 1118Sulfuric AcidHCID 5238Sodium IodideHCID 10340Sodium CarbonateHCID 516902Sodium ChlorateHCID 11757703β,β-Carotene-4,4'-diol

생성물 1

HCID 5281227Canthaxanthin수율 94,872.398%

시약·촉매·용매 2

HCID 962Water용매HCID 6212Chloroform용매

실험 절차

An aqueous solution of 3.2 g of sodium chlorate and 20 mg of sodium iodide, dissolved in 20 ml of water, is added to 500 mg of racemic isozeaxanthin dissolved in 50 ml of chloroform, the two-phase mixture is stirred thoroughly at room temperature, and 5 ml of 0.01N sulfuric acid is added. After an hour, the mixture is neutralized with dilute sodium carbonate solution, the phases are separated, and the organic phase is washed with water and dried over sodium sulfate. The solvent is distilled off under reduced pressure, 50 ml of heptane is added to the residue, and the whole is refluxed for 1 hour. After cooling, filtration gives 471 g (94% of theory) of canthaxanthin.

후처리

  1. waitAfter an hour
  2. customthe phases are separated
  3. washthe organic phase is washed with water
  4. dry with materialdried over sodium sulfate
  5. distillationThe solvent is distilled off under reduced pressure, 50 ml of heptane
  6. additionis added to the residue
  7. temperaturethe whole is refluxed for 1 hour
  8. temperatureAfter cooling
  9. filtrationfiltration

출처 및 근거

ORD 기록
ord-d995584d61d8457c8560b1023dcc81b7
출처 데이터셋
uspto-grants-1980_07
특허 번호
US04212827

연결된 노트

불러오는 중…