4-Coumaric acid → 2-Propenoic acid, 3-phenyl-

HRID 22094

반응식

HRID 22094 반응식
O[C:2]1[CH:12]=[CH:11][C:5]([CH:6]=[CH:7][C:8]([OH:10])=[O:9])=[CH:4][CH:3]=1>CS(C)=O>[C:8]([OH:10])(=[O:9])[CH:7]=[CH:6][C:5]1[CH:4]=[CH:3][CH:2]=[CH:12][CH:11]=1

참가 물질

3

반응물 1

HCID 3224-Coumaric acid

생성물 1

HCID 87842-Propenoic acid, 3-phenyl-

시약·촉매·용매 1

HCID 679Dimethyl Sulfoxide용매

반응 조건

온도
90 °C

실험 절차

2.8 g of p-hydroxy cinnamic acid was dissolved in 3 ml of DMSO, and 10 mg of sodium hydride of which the oil was washed by hexane was added. The mixture was stirred and heated to 90° C. under a flow of N2 gas. 5.0 g of glycidol was added gradually, heating and agitation were carried out for 1.5 hours, neutralized by adding hydrochloric acid and then the adduct of cinnamic acid and glycerin was obtained.

후처리

  1. wash10 mg of sodium hydride of which the oil was washed by hexane
  2. additionwas added
  3. addition5.0 g of glycidol was added gradually
  4. temperatureheating
  5. additionby adding hydrochloric acid

출처 및 근거

ORD 기록
ord-2231e991bda54208932c1c846850f007
출처 데이터셋
uspto-grants-1995_06
특허 번호
US05426210

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