Diethyl chlorophosphate → HCID 178475398, 화합물

HRID 2225535

반응식

HRID 2225535 반응식
[C:1]([O:4][C:5]1[CH:6]=[C:7]([CH:13]=[CH:14][C:15]=1[O:16][C:17](=[O:19])[CH3:18])[CH:8]=[CH:9][C:10]([OH:12])=O)(=[O:3])[CH3:2].C(O)(=O)/C=C/C1C=CC(O)=C(O)C=1.P(Cl)(OCC)(OCC)=O.[CH3:42][N:43]([CH3:54])[CH2:44][CH2:45][NH:46][C@H:47]1[CH2:52][CH2:51][C@H:50]([CH3:53])[CH2:49][CH2:48]1>CN(C)C1C=CN=CC=1.C(Cl)Cl.C(N(CC)CC)C>[CH3:42][N:43]([CH3:54])[CH2:44][CH2:45][N:46]([C@H:47]1[CH2:48][CH2:49][C@H:50]([CH3:53])[CH2:51][CH2:52]1)[C:10](=[O:12])[CH:9]=[CH:8][C:7]1[CH:13]=[CH:14][C:15]([O:16][C:17](=[O:19])[CH3:18])=[C:5]([O:4][C:1](=[O:3])[CH3:2])[CH:6]=1

참가 물질

8

반응물 4

HCID 13139Diethyl chlorophosphateHCID 991033,4-Diacetoxycinnamic acidHCID 689043Caffeic AcidHCID 178483797HCID 178483797, 화합물

생성물 1

HCID 178475398HCID 178475398, 화합물

시약·촉매·용매 3

HCID 142844-(Dimethylamino)pyridine촉매HCID 6344Dichloromethane용매HCID 8471Triethylamine용매

실험 절차

Using 3.4 g of 3,4-diacetoxycinnamic acid derived from caffeic acid by the acetylation thereof, 2.8 ml of diethyl chlorophosphate, 2.7 ml of triethylamine, 100 ml of methylene chloride, 3.0 ml of N-(2-dimethylaminoethyl)-trans-4-methylcyclohexylamine (Example 78), and 0.5 g of 4-dimethylaminopyridine, a reaction similar to that conducted in Example 81 was carried out. As a result, 0.68 g of N-(2-dimethylaminoethyl)-N-(trans-4-methylcyclohexyl)-3,4-diacetoxycinnamamide (a compound of the present invention) was obtained as pale yellow crystal, which had the following physiochemical properties:

출처 및 근거

ORD 기록
ord-2991a9b4149447f3a582a4b3de1d9c97
출처 데이터셋
uspto-grants-1994_09
특허 번호
US05344845

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