Hydrochloric Acid → Acetophenone, 2',4'-dichloro-5'-fluoro-

HRID 248499

반응식

HRID 248499 반응식
[Cl:1][C:2]1[CH:7]=[CH:6][C:5]([F:8])=[C:4]([Cl:9])[CH:3]=1.[Cl-].[Al+3].[Cl-].[Cl-].[C:14](OC(=O)C)(=[O:16])[CH3:15].Cl>>[C:14]([C:7]1[C:2]([Cl:1])=[CH:3][C:4]([Cl:9])=[C:5]([F:8])[CH:6]=1)(=[O:16])[CH3:15]

참가 물질

5

반응물 4

HCID 313Hydrochloric AcidHCID 7918Acetic AnhydrideHCID 123112Benzene, 2,4-dichloro-1-fluoro-HCID 6451240Aluminum(III) Chloride

생성물 1

HCID 727250Acetophenone, 2',4'-dichloro-5'-fluoro-

반응 조건

온도
80 °C

실험 절차

A mixture of 229.6 g of 1,3-dichloro-4-fluorobenzene and 205.34 g of aluminum chloride was heated at 80° C. A 56 g portion of acetic anhydride was added dropwise over 2 hours, then the reaction ws heated at 100° C. for 8 hours, poured onto a mixture of concentrated hydrochloric acid and ice and extracted several times with ether. The ether extracts were combined, washed with water, dried and the solvents evaporated. The solid was purified by vacuum distillation, giving 156.63 g of 6-acetyl-1,3-dichloro-4-fluorobenzene.

후처리

  1. temperaturethe reaction ws heated at 100° C. for 8 hours
  2. extractionextracted several times with ether
  3. washwashed with water
  4. customdried
  5. customthe solvents evaporated
  6. distillationThe solid was purified by vacuum distillation

출처 및 근거

ORD 기록
ord-37d187f7d13144d49ee81d90538374b3
출처 데이터셋
uspto-grants-1993_05
특허 번호
US05210193

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