Benzyl Chloride → 4-Benzyloxybenzonitrile
반응식
[H-].[Na+].[OH:3][C:4]1[CH:11]=[CH:10][C:7]([C:8]#[N:9])=[CH:6][CH:5]=1.[H][H].[CH2:14](Cl)[C:15]1[CH:20]=[CH:19][CH:18]=[CH:17][CH:16]=1>CN(C=O)C.O>[CH2:14]([O:3][C:4]1[CH:11]=[CH:10][C:7]([C:8]#[N:9])=[CH:6][CH:5]=1)[C:15]1[CH:20]=[CH:19][CH:18]=[CH:17][CH:16]=1참가 물질
7
반응 조건
- 온도
- 0 °C
실험 절차
5.10-2 mol of NaH was added little by little to a solution of 5.10-2 mol of 4-hydroxy benzonitrile in 100 ml DMF so as to obtain a temperature of 25° C. The solution was then heated to 50° C. until no more hydrogen was liberated. After cooling to 0° C., 5.10-2 benzyl chloride was added. The reaction mixture was heated to 40° C. for 1 hour, then poured into 300 ml iced water. The resulting solid was separated by filtration.
후처리
- customto obtain a temperature of 25° C
- temperatureThe reaction mixture was heated to 40° C. for 1 hour
- customThe resulting solid was separated by filtration
출처 및 근거
- ORD 기록
- ord-e50281e58a75463cba831780f7fec132
- 출처 데이터셋
- uspto-grants-1993_11
- 특허 번호
- US05262432
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