Benzyl Chloride → 4-Benzyloxybenzonitrile

HRID 257454

반응식

HRID 257454 반응식
[H-].[Na+].[OH:3][C:4]1[CH:11]=[CH:10][C:7]([C:8]#[N:9])=[CH:6][CH:5]=1.[H][H].[CH2:14](Cl)[C:15]1[CH:20]=[CH:19][CH:18]=[CH:17][CH:16]=1>CN(C=O)C.O>[CH2:14]([O:3][C:4]1[CH:11]=[CH:10][C:7]([C:8]#[N:9])=[CH:6][CH:5]=1)[C:15]1[CH:20]=[CH:19][CH:18]=[CH:17][CH:16]=1

참가 물질

7

반응물 4

HCID 7503Benzyl ChlorideHCID 130194-CyanophenolHCID 24758Sodium hydrideHCID 178418361HCID 178418361, 화합물

생성물 1

HCID 5613714-Benzyloxybenzonitrile

시약·촉매·용매 2

HCID 962Water용매HCID 6228Dimethylformamide용매

반응 조건

온도
0 °C

실험 절차

5.10-2 mol of NaH was added little by little to a solution of 5.10-2 mol of 4-hydroxy benzonitrile in 100 ml DMF so as to obtain a temperature of 25° C. The solution was then heated to 50° C. until no more hydrogen was liberated. After cooling to 0° C., 5.10-2 benzyl chloride was added. The reaction mixture was heated to 40° C. for 1 hour, then poured into 300 ml iced water. The resulting solid was separated by filtration.

후처리

  1. customto obtain a temperature of 25° C
  2. temperatureThe reaction mixture was heated to 40° C. for 1 hour
  3. customThe resulting solid was separated by filtration

출처 및 근거

ORD 기록
ord-e50281e58a75463cba831780f7fec132
출처 데이터셋
uspto-grants-1993_11
특허 번호
US05262432

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