Diethyl Sulfate → 2-Bromophenetole

HRID 31343

반응식

HRID 31343 반응식
[Br:1][C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][C:3]=1[OH:8].S(OCC)(O[CH2:13][CH3:14])(=O)=O>[OH-].[Na+]>[Br:1][C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][C:3]=1[O:8][CH2:13][CH3:14]

참가 물질

4

반응물 2

HCID 6163Diethyl SulfateHCID 72442-Bromophenol

생성물 1

HCID 685002-Bromophenetole

시약·촉매·용매 1

HCID 14798Sodium Hydroxide용매

실험 절차

A mixture of 17.5 g of 2-bromophenol, 66 ml of diethyl sulphate and 170 ml of 10% NaOH solution is refluxed for 2 hours. After cooling the reaction mixture to RT, it is extracted with EtOAc, the organic phase is washed with 2N NaOH solution and dried over Na2SO4, and the solvent is evaporated off under vacuum. 19.6 g of the expected product are obtained.

후처리

  1. temperatureis refluxed for 2 hours
  2. extractionit is extracted with EtOAc
  3. washthe organic phase is washed with 2N NaOH solution
  4. dry with materialdried over Na2SO4
  5. customthe solvent is evaporated off under vacuum

출처 및 근거

ORD 기록
ord-7430bb1eac354422a753a5f7420cbe7a
출처 데이터셋
uspto-grants-2008_09
특허 번호
US07425566B2

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