Hydrochloric Acid → N-Acetyl-S-methyl-L-cysteine

HRID 325331

반응식

HRID 325331 반응식
[CH3:1][S:2][CH2:3][C@@H:4]([C:6]([OH:8])=[O:7])[NH2:5].[C:9](OC(=O)C)(=[O:11])[CH3:10].Cl>[OH-].[Na+]>[CH3:1][S:2][CH2:3][C@@H:4]([C:6]([OH:8])=[O:7])[NH:5][C:9](=[O:11])[CH3:10]

참가 물질

5

반응물 3

HCID 313Hydrochloric AcidHCID 7918Acetic AnhydrideHCID 24417(-)-S-Methyl-L-cysteine

생성물 1

HCID 13893975N-Acetyl-S-methyl-L-cysteine수율 89.7%

시약·촉매·용매 1

HCID 14798Sodium Hydroxide용매

실험 절차

A solution of 13.5 g (100 mmole) of S-methyl-L-cysteine dissolved in 210 ml of 1 N sodium hydroxide solution was ice cooled and 10.4 ml (110 mmole) of acetic anhydride was added thereto dropwise. After 2.0 hours at room temperature, the mixture was acidified to pH 1.0 with 6 N hydrochloric acid and extracted with ethyl acetate. The extract was dried over anhydrous magnesium sulfate and concentrated in vacuo to give 15.9 g (89.6% yield) of S-methyl-N-acetyl-L-cysteine as an oil.

후처리

  1. temperaturecooled
  2. extractionextracted with ethyl acetate
  3. dry with materialThe extract was dried over anhydrous magnesium sulfate
  4. concentrationconcentrated in vacuo

출처 및 근거

ORD 기록
ord-1289b227d0be43a18e1a3d5cb961e5a3
출처 데이터셋
uspto-grants-1984_04
특허 번호
US04440788

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