DL-Arabinose → calcium pectinate Eudragit

HRID 356790

반응식

HRID 356790 반응식
C([O-])(=O)C1C(=CC=CC=1)O.[Na+].C1C=C(CC([O-])=O)C(NC2C(Cl)=CC=CC=2Cl)=CC=1.[Na+].[CH2:32]([OH:41])[CH:33]([OH:40])[CH:34]([OH:39])[CH:35]([OH:38])[CH:36]=[O:37].[Ca].[Cl-].[Ca+2].[Cl-].C(=O)CCCC=O.[CH3:53][C:54]([C:56]([O:58][CH3:59])=[O:57])=[CH2:55]>C(O)C.O.C(O)(C)C>[CH2:32]([OH:41])[CH:33]([OH:40])[CH:34]([OH:39])[CH:35]([OH:38])[CH:36]=[O:37].[CH3:55][C:54]([C:56]([O:58][CH3:59])=[O:57])=[CH2:53]

참가 물질

10

반응물 7

HCID 854DL-Arabinose7회HCID 3485GlutaraldehydeHCID 6658Methyl Methacrylate3회HCID 5018304Diclofenac sodiumHCID 5284359Calcium ChlorideHCID 5460341CalciumHCID 16760658Sodium Salicylate3회

생성물 1

HCID 131720951calcium pectinate Eudragit

시약·촉매·용매 2

HCID 702Ethanol용매3회HCID 21889133Propan-2-ol--water (1/1)용매

실험 절차

Eudragit E™ 100 and Eudragit RS™ were purchased from Rohm Pharma (Germany). Ethyl Cellulose was purchased from Hercules (USA). Sodium salicylate powder (BP, USP) was supplied by Merck (Germany). Sodium diclofenac was purchased from Prosintex (UK). Ethyl alcohol was USP grade. Calcium pectinate powder containing 4% and 2% calcium was prepared by the addition of calcium chloride to a suspension of low methoxy pectin (Copenhagen Pectin) in a water/isopropyl alcohol mixture. Pectin/calcium pectinate core tablets which weighed ~300 mg and contained 30 mg sodium salicylate were prepared by standard dry granulation techniques. Microcrystalline cellulose core tablets weighing 250 mg and containing 30 mg sodium salicylate, were prepared by dry granulation techniques. Pectin/calcium pectinate core tablets weighing ~300 mg and containing 100 mg sodium diclofenac were prepared by standard dry granulation techniques. Crospovidone was purchased from GAF (USA). Crosslinked Byco gelatin was prepared by a crosslinking reaction of Byco hydrolyzed gelatin (Croda (UK)) with glutaraldehyde (Merck (Germany)). Microcrystalline cellulose was purchased from FMC (Belgium). The coating calcium pectinate/Eudragit™ suspension was prepared by dissolving Eudragit E™ (10% w/v (22.5 g Eudragit™/200 g solution)) in ethanol and then adding the calcium pectinate powder, to the desired weight ratio of, 70, 50 and 30% (g calcium pectinate/g Eudragit™ plus calcium pectinate), to the Eudragit™ solution. The suspension was then continuously stirred vigorously throughout the coating process to prevent the calcium pectinate deposition. The other polymer--particulate combinations were prepared similarly by first dissolving the polymer (Eudragit RS™ or ethylcellulose) in ethanol and then adding the particulate (calcium pectinate, Crospovidone, microcrystalline cellulose, or crosslinked Byco protein).

후처리

  1. customwere prepared by standard dry granulation techniques
  2. customwere prepared
  3. customby dry granulation techniques
  4. additioncontaining 100 mg sodium diclofenac
  5. customwere prepared by standard dry granulation techniques
  6. customThe other polymer--particulate combinations were prepared similarly

출처 및 근거

ORD 기록
ord-7a85cf612d2544c285b7c69b08186445
출처 데이터셋
uspto-grants-1998_11
특허 번호
US05840332

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