Indole-3-pyruvic acid → HCID 54134943, 화합물

HRID 359727

반응식

HRID 359727 반응식
C[N-]C.[NH:4]1[C:12]2[C:7](=[CH:8][CH:9]=[CH:10][CH:11]=2)[C:6]([CH2:13][C:14](=[O:18])[C:15]([OH:17])=O)=[CH:5]1.[CH:19]1[CH:20]=[CH:21][C:22]2N(O)N=[N:25][C:23]=2[CH:24]=1.C1(N)CCCCC1.CN1CCOCC1>CCN=C=NCCCN(C)C.Cl>[CH:23]1([NH:25][C:15](=[O:17])[C:14]([CH2:13][C:6]2[C:7]3[C:12](=[CH:11][CH:10]=[CH:9][CH:8]=3)[NH:4][CH:5]=2)=[O:18])[CH2:24][CH2:19][CH2:20][CH2:21][CH2:22]1

참가 물질

7

반응물 5

HCID 803Indole-3-pyruvic acidHCID 7965CyclohexylamineHCID 79724-MethylmorpholineHCID 757711-HydroxybenzotriazoleHCID 182180Dimethylazanide

생성물 1

HCID 54134943HCID 54134943, 화합물

시약·촉매·용매 1

HCID 27239391,3-Propanediamine, N'-(ethylcarbonimidoyl)-N,N-dimethyl-, monohydrochloride용매

실험 절차

The same method as described in Example 7 was followed for the preparation of N,N-dimethylamide. 500 mg 3-indolepyruvic acid were reacted with 400 ml HOBt and 570 ml EDC.HCl. 340 microliters of freshly distilled cyclohexylamine and 325 microliters NMM were added to the solution, which was reacted for 5 hours.

후처리

  1. customwas reacted for 5 hours

출처 및 근거

ORD 기록
ord-ab4f0216453f46f89472cb195305881f
출처 데이터셋
uspto-grants-1991_03
특허 번호
US05002963

연결된 노트

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