Hydrochloric Acid → Acetamide, 2-(hydroxyimino)-N-phenyl-

HRID 51980

반응식

HRID 51980 반응식
[NH:1]1[C:11]2[C:6](=[CH:7][CH:8]=[CH:9][CH:10]=2)[C:4](=O)[C:2]1=[O:3].O=CC(Cl)(Cl)Cl.[Cl-].[OH:19][NH3+:20].Cl.NC1C=CC=CC=1>>[CH:8]1[CH:7]=[CH:6][C:11]([NH:1][C:2](/[CH:4]=[N:20]/[OH:19])=[O:3])=[CH:10][CH:9]=1

참가 물질

6

반응물 5

HCID 313Hydrochloric AcidHCID 6115AnilineHCID 6407ChloralHCID 7054IsatinHCID 21645Hydroxylamine HCl

생성물 1

HCID 6861488Acetamide, 2-(hydroxyimino)-N-phenyl-

실험 절차

The isatin derivative (9) can be synthesized, for example, as shown in the following reaction scheme. That is, an aqueous solution obtained by adding chloral and hydroxylammonium chloride to hydrochloride of an aniline derivative (10) as a starting material is reacted for 0.5 to 2 hours with heating at 70° to 110° C. to give an isonitrosoacetanilide derivative, and this product is cyclized with concentrated sulfuric acid and hydrolyzed to give an isatin derivative (9). ##STR10## wherein R1A to R1D are as defined above.

후처리

  1. customas shown in the following reaction scheme
  2. customan aqueous solution obtained
  3. customis reacted for 0.5 to 2 hours
  4. temperaturewith heating at 70° to 110° C.

출처 및 근거

ORD 기록
ord-e75f94cdfd09486eb81e090e8b1e9b65
출처 데이터셋
uspto-grants-1997_04
특허 번호
US05616441

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