Acetic Anhydride → HCID 67151807, 화합물

HRID 551492

반응식

HRID 551492 반응식
[NH2:1][C:2]1[C:3]([CH3:10])=[C:4]([CH:7]=[CH:8][CH:9]=1)[CH2:5][OH:6].C(O[C:15](=[O:17])[CH3:16])(=O)C.[C:18]([O-:21])(=O)[CH3:19].[K+].[N:23](OCCC(C)C)=O.C1OCCOCCOCCOCCOCCOC1>C(Cl)(Cl)Cl>[C:18]([N:1]1[C:2]2[C:3](=[C:4]([CH2:5][O:6][C:15](=[O:17])[CH3:16])[CH:7]=[CH:8][CH:9]=2)[CH:10]=[N:23]1)(=[O:21])[CH3:19]

참가 물질

7

반응물 5

HCID 7918Acetic AnhydrideHCID 8053Isoamyl NitriteHCID 2855718-Crown-6HCID 517044Potassium AcetateHCID 577175(3-Amino-2-methylphenyl)methanol

생성물 1

HCID 67151807HCID 67151807, 화합물

시약·촉매·용매 1

HCID 6212Chloroform용매

실험 절차

3-Amino-2-methyl benzyl alcohol (0.82 g, 5.98 mmol), acetic anhydride (1.68 mL, 17.8 mmol), potassium acetate (1.75 g, 17.8 mol), isoamyl nitrite (1.82 mL, 13.7 mmol) and 18-crown-6 (79 mg, 0.3 mmol) in 25 mL CHCl3 were reacted as described in EP99/07620. The crude product was purified by flash chromatography with a gradient from 0-35% ethyl acetate in hexanes to yield acetic acid 1-acetyl-1H-indazol-4-ylmethyl ester.

후처리

  1. customThe crude product was purified by flash chromatography with a gradient from 0-35% ethyl acetate in hexanes

출처 및 근거

ORD 기록
ord-b5aad79e57074a91ad948f17d033bbb6
출처 데이터셋
uspto-grants-2011_05
특허 번호
US07947728B1

연결된 노트

불러오는 중…