Hydrochloric Acid → 4-[(6-Chloropyridazin-3-yl)oxy]aniline

HRID 67158

반응식

HRID 67158 반응식
[H-].[Na+].[NH2:3][C:4]1[CH:9]=[CH:8][C:7]([OH:10])=[C:6](Cl)[CH:5]=1.[Cl:12][C:13]1[N:14]=[N:15][C:16](Cl)=[CH:17][CH:18]=1.Cl>CS(C)=O>[Cl:12][C:13]1[N:14]=[N:15][C:16]([O:10][C:7]2[CH:8]=[CH:9][C:4]([NH2:3])=[CH:5][CH:6]=2)=[CH:17][CH:18]=1

참가 물질

6

반응물 4

HCID 313Hydrochloric AcidHCID 24758Sodium hydrideHCID 673313,6-DichloropyridazineHCID 775784-Amino-2-chlorophenol

생성물 1

HCID 106805234-[(6-Chloropyridazin-3-yl)oxy]aniline

시약·촉매·용매 1

HCID 679Dimethyl Sulfoxide용매

실험 절차

12 g of sodium hydride was added in portions to a stirred solution of 71.8 g of 1A and 25 g of 3,6-dichloropyridazine in 300 ml of dimethyl sulfoxide, the temperature of the mixture being held at 50° C. The mixture then was stirred for one hour and poured into ice water. The mixture was slightly acidified with dilute hydrochloric acid, and was extracted with methylene chloride. The extract was washed with water, dried (magnesium sulfate) and the solvent was evaporated to give 4-(6-chloro-3-pyridazinyloxy)benzeneamine (1B), as a tan solid, mp: 126°-129° C.

후처리

  1. custombeing held at 50° C
  2. extractionwas extracted with methylene chloride
  3. washThe extract was washed with water
  4. dry with materialdried (magnesium sulfate)
  5. customthe solvent was evaporated

출처 및 근거

ORD 기록
ord-3c0a74c576584da0a7ede398eec0b46b
출처 데이터셋
uspto-grants-1982_08
특허 번호
US04345076

연결된 노트

불러오는 중…