Chloroacetic Acid → [(2-Propanylideneamino)oxy]acetic acid

HRID 747077노트

반응식

HRID 747077 반응식
[CH3:1][C:2](=[N:4][OH:5])[CH3:3].Cl[CH2:7][C:8]([OH:10])=[O:9].[OH-].[Na+]>[Br-].C([N+](CCCC)(CCCC)CCCC)CCC.C1(C)C=CC=CC=1>[CH3:1][C:2](=[N:4][O:5][CH2:7][C:8]([OH:10])=[O:9])[CH3:3]

참가 물질

6

반응물 3

HCID 300Chloroacetic AcidHCID 14798Sodium HydroxideHCID 67180Acetone, oxime

생성물 1

HCID 79344[(2-Propanylideneamino)oxy]acetic acid

시약·촉매·용매 2

HCID 74236Tetrabutylammonium Bromide촉매HCID 1140Toluene용매

실험 절차

7.3 g of acetone oxime, 14.2 g of chloroacetic acid and 2% of tetrabutylammonium bromide are placed in 80 ml of toluene. An aqueous sodium hydroxide solution (10 g of sodium hydroxide dissolved in 150 ml of water) is added dropwise. The reaction medium is stirred for 1 h and then the toluene is evaporated under vacuum. The residue is then acidified with concentrated hydrochloric acid to pH 2.5, then washed with water and extracted twice with ethyl acetate. The organic phase is dried over sodium sulfate and the solvent is evaporated to give the expected product.

후처리

  1. customthe toluene is evaporated under vacuum
  2. washwashed with water
  3. extractionextracted twice with ethyl acetate
  4. dry with materialThe organic phase is dried over sodium sulfate
  5. customthe solvent is evaporated

출처 및 근거

ORD 기록
ord-20988d9a1e434193b54ddb81c32a440b
출처 데이터셋
uspto-grants-2008_07
특허 번호
US07396525B2

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