Benzylamine → HCID 178418897, 화합물

반응식

[CH2:1]([NH2:8])[C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][CH:3]=1.FC(F)(F)S(O[Si](C)(C)C)(=O)=O.[OH-].[Na+].[CH2:23]([S:25][C:26]#[N:27])[CH3:24]>>[CH2:1]([NH:8][C:26](=[NH:27])[S:25][CH2:23][CH3:24])[C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][CH:3]=1

참가 물질

반응물 4

HCID 7504Benzylamine

HCID 10968Ethyl thiocyanate

HCID 14798Sodium Hydroxide

HCID 65367Trimethylsilyl triflate

생성물 1

HCID 178418897HCID 178418897, 화합물수율 100%

실험 절차

Benzylamine (13.8 mg) was dissolved in ethyl thiocyanate (50 μl). To this solution, trimethylsilyl trifluoromethanesulfonate (25.7 μl) was added dropwise at room temperature. After continued stirring for 1 day at room temperature, 2N aqueous sodium hydroxide was added to the solution, which was then extracted with ethyl acetate. The ethyl acetate layer was dried over anhydrous sodium sulfate and concentrated under reduced pressure to give the titled compound (25.4 mg, yield 100%).

후처리

extractionwas then extracted with ethyl acetate
dry with materialThe ethyl acetate layer was dried over anhydrous sodium sulfate
concentrationconcentrated under reduced pressure

출처 및 근거

ORD 기록: ord-7db99835b713471dac9c78ee60d5003c
출처 데이터셋: uspto-grants-2006_08
DOI: 10.6084/m9.figshare.5104873.v1
특허 번호: US07087783B2

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