반응식
[CH2:1](Cl)[C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][CH:3]=1.[C:9]1([S:15](Cl)(=[O:17])=[O:16])[CH:14]=[CH:13][CH:12]=[CH:11][CH:10]=1.CC([O-])(C)C.[K+].[Li+].[OH-].[NH2:27][O:28]C1CCCCO1.C1CN([P+](ON2N=[N:59][C:54]3[CH:55]=CC=CC2=3)(N2CCCC2)N2CCCC2)CC1.F[P-](F)(F)(F)(F)F.C(O)(C(F)(F)F)=[O:69]>CO.CN(C=O)C.CCN(CC)CC.O1CCOCC1>[OH:28][NH:27][C:1]([C:2]1[CH:7]=[C:6]2[C:5](=[CH:4][CH:3]=1)[N:59]([S:15]([C:9]1[CH:14]=[CH:13][CH:12]=[CH:11][CH:10]=1)(=[O:17])=[O:16])[CH:54]=[CH:55]2)=[O:69]참가 물질
12
반응물 7
생성물 1
시약·촉매·용매 4
실험 절차
Compound 1 was synthesized via the route as shown in Scheme 1 above (reagents and conditions: a) benzyl chloride or benzenesulfonyl chloride, t-BuOK, KI, DMF; b) 1M LiOH(aq), dioxane; c) (i) NH2OTHP, PyBOP, NEt3, DMF, rt; (ii) TFA, MeOH, rt).
출처 및 근거
- ORD 기록
- ord-0920744fda3c4b1fb38ee5c46c52898b
- 출처 데이터셋
- uspto-grants-2014_09
- 특허 번호
- US08846748B2
연결된 노트
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