홈MCP워크벤치Skills
홈워크벤치알림마이페이지
llms.txt · MCP 가이드개인정보처리방침 · 이용약관 · 지원v1.8.0
  1. 홈
  2. /반응

Lithium Hydroxide → 1-benzenesulfonyl-1H-indole-5-carboxylic acid hydroxyamide

HRID 84177
노트
인쇄 미리보기

반응식

HRID 84177 반응식
[CH2:1](Cl)[C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][CH:3]=1.[C:9]1([S:15](Cl)(=[O:17])=[O:16])[CH:14]=[CH:13][CH:12]=[CH:11][CH:10]=1.CC([O-])(C)C.[K+].[Li+].[OH-].[NH2:27][O:28]C1CCCCO1.C1CN([P+](ON2N=[N:59][C:54]3[CH:55]=CC=CC2=3)(N2CCCC2)N2CCCC2)CC1.F[P-](F)(F)(F)(F)F.C(O)(C(F)(F)F)=[O:69]>CO.CN(C=O)C.CCN(CC)CC.O1CCOCC1>[OH:28][NH:27][C:1]([C:2]1[CH:7]=[C:6]2[C:5](=[CH:4][CH:3]=1)[N:59]([S:15]([C:9]1[CH:14]=[CH:13][CH:12]=[CH:11][CH:10]=1)(=[O:17])=[O:16])[CH:54]=[CH:55]2)=[O:69]
참가 물질실험 절차출처 및 근거반응 노트

참가 물질

12

반응물 7

HCID 3939Lithium HydroxideHCID 6422Trifluoroacetic acidHCID 7369Benzenesulfonyl chlorideHCID 7503Benzyl ChlorideHCID 2724699PyBOPHCID 5142091O-(Tetrahydropyran-2-yl)hydroxylamineHCID 23665647Potassium tert-butoxide

생성물

1
HCID 534645751-benzenesulfonyl-1H-indole-5-carboxylic acid hydroxyamide

시약·촉매·용매 4

HCID 887Methanol용매HCID 6228Dimethylformamide용매2회HCID 8471Triethylamine용매HCID 312751,4-Dioxane용매

실험 절차

Compound 1 was synthesized via the route as shown in Scheme 1 above (reagents and conditions: a) benzyl chloride or benzenesulfonyl chloride, t-BuOK, KI, DMF; b) 1M LiOH(aq), dioxane; c) (i) NH2OTHP, PyBOP, NEt3, DMF, rt; (ii) TFA, MeOH, rt).

출처 및 근거

ORD 기록
ord-0920744fda3c4b1fb38ee5c46c52898b
출처 데이터셋
uspto-grants-2014_09
DOI
10.6084/m9.figshare.5104873.v1
특허 번호
US08846748B2

반응 노트

불러오는 중…

이 페이지에서참가 물질실험 절차출처 및 근거반응 노트