反应详情

(R)-4-Hydroxymandelic acid (2.02 g) was dissolved in N,N-dimethylformamide (24 ml), and benzyl bromide (3.57 ml) and potassium carbonate (3.65 g) were added to the solution at room temperature with stirring. After reaction for 12 hours, ice-water was poured into the reaction mixture and the resulting precipitates were collected by filtration. The precipitates were suspended in methanol (24 ml) and 1N aqueous sodium hydroxide solution (12 ml) was added to the suspension under ice-cooling with stirring. After reaction at room temperature for 2 hours, 1N hydrochloric acid (12 ml) was added to the reaction mixture under ice-cooling with stirring. Collection by filtration of the resulting precipitates gave (R)-4-benzyloxymandelic acid (2.43 g) having a melting point of 161-163° C.

1. customAfter reaction for 12 hours
2. customthe resulting precipitates
3. filtrationwere collected by filtration
4. addition1N aqueous sodium hydroxide solution (12 ml) was added to the suspension under ice-
5. temperaturecooling
6. stirringwith stirring
7. customAfter reaction at room temperature for 2 hours
8. temperaturecooling
9. stirringwith stirring
10. customCollection
11. filtrationby filtration of the resulting
12. customprecipitates